Optimization of resting tension for wire myography in male rat pulmonary arteries
Rira Choi,
Roshini Narayanan,
Sandeep Jandu
et al.
Abstract:Wire myography to test vasomotor functions of blood vessels ex‐vivo are well‐established for the systemic circulation, however, there is no consensus on protocols for pulmonary arteries. We created a standardized wire myography protocol for healthy rat PAs and validated this in a pulmonary hypertension (PH) model. Vessels stretched to higher initial tensions (5.0, 7.5 and 10.0 mN) exhibited a uniform response to phenylephrine, a larger dynamic range, and lower EC50 values. The endothelium‐mediated relaxation s… Show more
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