The variable-criteria sequential stopping rule (SSR) is a method that allows investigators to conduct nullhypothesis significance tests in stages with a few subjects at a time until the null hypothesis is rejected or the experiment is stopped because the obtained p value is so high that it is unlikely that the experiment will succeed (Fitts, 2010). This method controls the rate of Type I errors near the nominal value, such as .05, and maintains excellent power. It allows an investigator to progress intuitively through an experiment without investing large amounts of effort, resources, and subjects all at once. The method also stops experiments early when it is obvious that the null hypothesis is not likely to be rejected, and thus, it saves subjects. For this reason, the method is highly recommended for research when a null hypothesis test is appropriate (Frick, 1996) and when it is imperative to use as few subjects as possible because the subjects are rare or expensive or because the treatments cause pain or distress (e.g., experimental surgeries, tests of pain medication). An SSR is not helpful for creating confidence intervals of small size, because small confidence intervals require large sample sizes. The technique is useful mostly when the researcher is satisfied to know whether an effect exists and, if so, in which direction. My original study (Fitts, 2010) did not validate the use of the variable-criteria SSR with more than four groups in an ANOVA or provide guidance on how to use the method if sample size is lost from one or more groups during the experiment. That is the aim of the present study.The variable-criteria SSR contrasts with the fixed stopping rule, which does not share its benefits. The fixed stopping rule is the customary method for conducting a null hypothesis test, in which the investigator does a power analysis to determine the sample size for the groups, collects data on all subjects, and then analyzes the data with a significance test, such as a t test, once and for all. If the p value is less than alpha (e.g., .05), the investigator rejects the null hypothesis and declares the result significant. If the p value is greater than alpha, little can be concluded. The null hypothesis has not been proven, because the experiment may lack the power to detect an effect of that size. The investigator must not add sample size to the experiment at this point, because the alpha selected for the experiment, such as .05, is constant only for a single test of the null hypothesis. If the investigator adds sample size and compares the new p value with the same criterion of .05, the observed rate of Type I errors will rapidly rise above .05 to unacceptable levels. This leads to an increased publication of unreplicable results.The use of the variable-criteria SSR to control alpha is explained in detail in Fitts (2010). The present method is a variation of previous stopping rules originated by Frick (1998) and modified by Botella, Ximénez, Revuelta, and Suero (2006) and Ximénez and Revuelta (2007). These e...