Optimization of selenylation conditions for lycium barbarum polysaccharide based on antioxidant activity

Qiu, Shulei; Chen, Jin; Chen, Xi; Fan, Qin; Zhang, Cunshuai; Wang, Deyun; Li, Xiuping; Chen, Xingying; Chen, Xiaolan; Liu, Cui; Gao, Zhenzhen; Li, Hongquan; Hu, Yuanliang

doi:10.1016/j.carbpol.2013.12.032

Cited by 96 publications

(34 citation statements)

References 18 publications

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“…Molecular modification could change polysaccharides’ dimensional structure, molecular weight, and the substituent groups’ types, number, and positions, with impacts on bioactivities. So far, there have been dozens of molecular modification methods, including carboxymethylation (Chen and others ), sulfation (Wang and others ), selenylation (Qiu and others ), phosphorylation (Yeand others ), ultrasonic disruption (Zhang and others ), and the degradation of polysaccharides, which are generally classified as chemical, physical, and biological modifications (Figure ).…”

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

410

172

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Polysaccharides are ideal natural resources for supplements and pharmaceuticals that have received more and more attention over the years. Natural polysaccharides have been shown to have fewer side effects, but because of their inherently physicochemical properties, their bioactivities were difficult to compare with those of synthetic drugs. Thus, researchers have modified the structures and properties of natural polysaccharides based on structure-activity relationships and have obtained better functionally improved polysaccharides. This review focuses on the major modification methods of polysaccharides, and discusses the effect of molecular modification on their physicochemical properties and bioactivities. Molecular modification methods mainly include chemical, physical, and biological changes. Chemical modification is the most widely used method; it can significantly increase the water solubility and bioactivities of polysaccharides by grafting onto other groups. Physical and biological modifications only change the molecular weight of a polysaccharide, and thereby change its physicochemical properties and bioactivities. Most of the molecular modifications bring about an increase in the antioxidant activity of polysaccharides, and among these, sulfated and acetylated modifications are very common. Furthermore, phosphorylation modification is the most common application to increase antitumor activity, and modified polysaccharides have been shown to have anti-HIV activity as the result of sulfated modification.

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Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

410

172

View full text Add to dashboard Cite

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“…Many earlier studies reported that the combination of selenium with polysaccharide into organic selenium polysaccharides could increase the activity compared to polysaccharide and selenium, they are simply absorbed and utilized by the body (Staaf and others ; Huang and others ; Liu and others ). Selenium polysaccharides were also used broadly in antioxidation immunomodulation, antiageing, antitumor, and so on (Qiu and others ). Therefore, application of SY and GA combination may be useful in reducing oxidative stress, inflammation, fibrogenesis and highly effective in treating and preventing chronic liver injury.…”

Section: Introductionmentioning

confidence: 99%

The Hepatoprotective Effect of Selenium‐Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride‐Induced Chronic Liver Injury in Rats

Hamid

Abdulrahim

Liu

et al. 2018

Journal of Food Science

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Chronic liver diseases are the serious health problems, which increase the morbidity and mortality in the world today. Selenium-enriched yeast (SY) and Gum Arabic (GA) combination might be potential dietary agents could obviously ameliorate chronic liver damage, higher than GA and SY alone. They act to suppress the inflammation and inhibit the profibrotic response as well as support the liver regeneration.

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“…The predominant LB components with antioxidant activity are peptidoglycans (also called LB polysaccharides, or LBP) (Qiu et al, 2014 andZhang, 1993); vitamin B, C, taurine, and carotenoids in fruits; while flavonoids, such as rutin prevail in the leaves (Jin et al 2013). The seeds of Fructus lycii also contain oils, which not only have antioxidant activity, but may improve skin barrier and decrease transepithelial water loss through their ability to interact with the lipid matrix of stratum corneum, such as it is the case of other bioactive oils (Tollesson and Frithz 1993).…”

Section: Skin Carementioning

confidence: 99%

Dermatologic Uses and Effects of Lycium Barbarum

Zhao

Bojanowski

2015

Lycium Barbarum and Human Health

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Lycium barbarum (LB) is one of the most intriguing medicinal plants in China. The beauty of its berries combined with the amount of beneficial effects assigned to it would logically make it a strong candidate for skin use, yet relatively few scientific publications address such application. Here, we will review the skin-related effects of oral and topical preparations of LB, based on the published scientific literature and work done in our own laboratory. We will also discuss the obstacles and opportunities for LB in today's dermatological field.

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Optimization of selenylation conditions for lycium barbarum polysaccharide based on antioxidant activity

Cited by 96 publications

References 18 publications

Molecular Modification of Polysaccharides and Resulting Bioactivities

Molecular Modification of Polysaccharides and Resulting Bioactivities

The Hepatoprotective Effect of Selenium‐Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride‐Induced Chronic Liver Injury in Rats

Dermatologic Uses and Effects of Lycium Barbarum

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