Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: Early characterization using the quality by design approach

Horne, Julie; De Bleye, Charlotte; Lebrun, Pierre; Kemik, Kevser; Van Laethem, Thomas; Sacré, Pierre-Yves; Hubert, Philippe; Hubert, Cédric; Ziemons, Eric

doi:10.1016/j.jpba.2023.115475

Cited by 16 publications

(3 citation statements)

References 32 publications

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“…Thus, potential interference occurs because these compounds have the capacity to adsorb onto the same site of plasmonic substrates, thereby competing for binding sites with the target analyte . In this context, customizing the SERS substrate to enhance DA signal while minimizing interference, optimizing the pH and ionic strength, and employing control experiments are crucial steps. − Additional experiments, such as spike recovery, would also improve confidence in claims assessing the specificity of the SERS technique.…”

Section: Resultsmentioning

confidence: 99%

Quantification of Plasma Dopamine in Depressed Patients Using Silver-Enriched Silicon Nanowires as SERS-Active Substrates

Gwon,

Kim,

Lee

2024

ACS Sens.

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A decrease in the levels of dopamine (DA)�a key catecholamine biomarker for major depressive disorder� highlights the need for quantitative analysis of biological fluids to aid in the early diagnosis of diverse neuropsychiatric disorders. This study developed silicon nanowires enriched with silver nanoparticles to serve as a surface-enhanced Raman scattering (SERS) substrate to enable precise and sensitive quantification of blood plasma DA levels in humans. The silver-enriched silicon nanowires (SiNWs@Ag) yielded flower-like assemblies with densely populated SERS "hot spots," allowing sensitive DA detection. By correlating DA concentration with Raman intensity at 1156 cm −1 , the plasma DA levels in treatment-nai ̈ve patients with major depression (n = 18) were 2 orders of magnitude lower than those in healthy controls (n = 18) (6.56 × 10 −10 M vs 1.43 × 10 −8 M). The plasma DA concentrations differed significantly between the two groups (two-tailed p = 5.77×10 -7 ), highlighting a distinct demarcation between depression patients and healthy controls. Furthermore, the SiNWs@Ag substrate effectively differentiated between DA and norepinephrine (NE) in mixtures at nanomolar levels, demonstrating its selective detection capability. This study represents the first report on the quantitative detection of DA levels in human blood samples from individuals with major depression using an SERS technique, emphasizing its potential clinical utility in the evaluation and diagnosis of neuropsychiatric disorders.

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Section: Resultsmentioning

confidence: 99%

Quantification of Plasma Dopamine in Depressed Patients Using Silver-Enriched Silicon Nanowires as SERS-Active Substrates

Gwon,

Kim,

Lee

2024

ACS Sens.

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“…AgNPs could be synthesized by all three possible methods, i.e ., chemical, physical, and biological ( Bouafia et al, 2021 ). The chemical approaches include chemical coprecipitation ( Adibah, Firdianti & Suprapto, 2023 ), sol-gel ( Shahjahan et al, 2017 ), chemical reduction ( Horne et al, 2023 ), polyol ( Wolf et al, 2022 ), etc . Among physical approaches, the most familiar ones are ball milling ( Lai et al, 2023 ), the vapor condensation method ( Simchi et al, 2007 ), arc discharge ( El-Khatib et al, 2018 ), and laser-ablation techniques ( Rafique et al, 2019 ; Juma et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Bacteriogenic synthesis of morphologically diverse silver nanoparticles and their assessment for methyl orange dye removal and antimicrobial activity

Patel,

Yadav,

Desai

et al. 2024

PeerJ

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Nanotechnology and nanoparticles have gained massive attention in the scientific community in recent years due to their valuable properties. Among various AgNPs synthesis methods, microbial approaches offer distinct advantages in terms of cost-effectiveness, biocompatibility, and eco-friendliness. In the present research work, investigators have synthesized three different types of silver nanoparticles (AgNPs), namely AgNPs-K, AgNPs-M, and AgNPs-E, by using Klebsiella pneumoniae (MBC34), Micrococcus luteus (MBC23), and Enterobacter aerogenes (MBX6), respectively. The morphological, chemical, and elemental features of the synthesized AgNPs were analyzed by using UV-Vis spectroscopy (UV-Vis), Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscope (FESEM) and energy-dispersive spectroscopy (EDX). UV-Vis absorbance peaks were obtained at 475, 428, and 503 nm for AgNPs-K, AgNPs-M, and AgNPs-E, respectively. The XRD analysis confirmed the crystalline nature of the synthesized AgNPs, having peaks at 26.2°, 32.1°, and 47.2°. At the same time, the FTIR showed bands at 599, 963, 1,693, 2,299, 2,891, and 3,780 cm−1 for all the types of AgNPs indicating the presence of bacterial biomolecules with the developed AgNPs. The size and morphology of the AgNPs varied from 10 nm to several microns and exhibited spherical to porous sheets-like structures. The percentage of Ag varied from 37.8% (wt.%) to 61.6%, i.e., highest in AgNPs-K and lowest in AgNPs-M. Furthermore, the synthesized AgNPs exhibited potential for environmental remediation, with AgNPs-M exhibiting the highest removal efficiency (19.24% at 120 min) for methyl orange dye in simulated wastewater. Further, all three types of AgNPs were evaluated for the removal of methyl orange dye from the simulated wastewater, where the highest dye removal percentage was 19.24% at 120 min by AgNPs-M. Antibacterial potential of the synthesized AgNPs assessment against both Gram-positive (GPB) Bacillus subtilis (MBC23), B. cereus (MBC24), and Gram-negative bacteria Enterococcus faecalis (MBP13) revealed promising results, with AgNPs-M, exhibiting the largest zone of inhibition (12 mm) against GPB B. megaterium. Such investigation exhibits the potential of the bacteria for the synthesis of AgNPs with diverse morphology and potential applications in environmental remediation and antibacterial therapy-based synthesis of AgNPs.

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“…The concept of green synthesis has garnered significant attention among nanotechnology researchers. Typically, the synthesis of nanoparticles, such as silver (Ag), gold (Au), and platinum (Pt), involves chemical and physical approaches [1][2][3]. However, the biological method has emerged as a more economically viable, eco-friendly, and non-toxic alternative for nanoparticle synthesis.…”

Section: Introductionmentioning

confidence: 99%

A One-Step Synthesis Novel Approach of Silver Nanoparticles Reduced by Aerodramus fuciphagus Extracts for Antibacterial Applications

Johari,

Halim,

Hussain

et al. 2023

Preprint

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Researchers are increasingly focusing on green synthesis methods for silver nanoparticles due to their cost-effectiveness and reduced environmental impact. In this study, we utilized an edible bird's nest (EBN), a valuable economic resource, as the primary material for synthesizing silver nanoparticles using only water as the solvent. Metabolite profiling of the EBN extract was conducted using LC-QTOF-MS in positive mode (ESI+), revealing the presence of lipids, glycosides, peptides, polysaccharides, and disaccharides. Upon the addition of silver nitrate to the aqueous EBN extract, noticeable color changes from transparent to brown indicated the successful formation of AgNPs. Subsequent characterization of these silver nanoparticles involved UV-Visible spectroscopy, which revealed an absorption peak at 421 nm. Further characterization was carried out using Field Effect Scanning Electron Microscopy (FESEM), Attenuated Total Reflectance-Fourier Infrared (ATR-FTIR) spectroscopy, and Energy Dispersive X-Ray (EDX) analysis. The involvement of phenolic agents, proteins, and amino acids in reducing the silver particles was confirmed. The synthesized nanoparticles exhibited a crystalline nature, a spherical shape, and a particle size ranging from 10 to 20 nm. The presence of elemental silver was confirmed by a strong, intense peak around 3 keV in the EDX spectrum. To assess their potential, the antibacterial properties of the silver nanoparticles against Escherichia coli and Staphylococcus aureus were evaluated using the agar diffusion method.

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Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: Early characterization using the quality by design approach

Cited by 16 publications

References 32 publications

Quantification of Plasma Dopamine in Depressed Patients Using Silver-Enriched Silicon Nanowires as SERS-Active Substrates

Quantification of Plasma Dopamine in Depressed Patients Using Silver-Enriched Silicon Nanowires as SERS-Active Substrates

Bacteriogenic synthesis of morphologically diverse silver nanoparticles and their assessment for methyl orange dye removal and antimicrobial activity

A One-Step Synthesis Novel Approach of Silver Nanoparticles Reduced by Aerodramus fuciphagus Extracts for Antibacterial Applications

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