Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets

Optimization of startup and shutdown operation of simulated moving bed chromatographic processes

“…However, both procedures are based on the equivalent TMB model, and the "triangle theory" neglects the effect of axial dispersion and mass transfer resistances. To overcome these limitations, alternative modelbased mathematical optimization strategies have been proposed [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. They consider a detailed dynamic SMB model, involve a single or multiple objective functions, and employ efficient solution techniques well developed in the mathematical programming community.…”

“…They consider a detailed dynamic SMB model, involve a single or multiple objective functions, and employ efficient solution techniques well developed in the mathematical programming community. With the ability to exploit the full process potential, they have been extensively used to optimize not only the standard SMB [14,15], but also many non-standard operations, such as VariCol [16,[19][20][21], PowerFeed [17,19,22], ModiCon [23], FF-SMB [24,25] and even the combination of different modes [18,19,26,27].…”

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

“…Since the discarded portion contains higher purity product than the feed, it follows that recycling the discarded portion into the SMB improves the separation performance. The loss of yield in the PD operation was successfully recovered in the FF‐SMB , and RPD‐SMB strategies by recycling the discarded portion during the feed stage.…”

“…In the Partial‐Feed and ModiCon operations, the feed is introduced only at a limited position where the compositions are similar to the feed compositions. The fractionation and feedback‐SMB (FF‐SMB) , , recycling partial discard‐SMB (RPD‐SMB) , FeedCol , and Backfill‐SMB operations generate raffinate‐rich and extract‐rich conditions in the front and rear parts of the feed profiles, respectively, during one switch period. As illustrated in Fig.…”

“…Feed concentration profiles in (a) Partial‐Feed and ModiCon strategies, (b) FF‐SMB , , RPD‐SMB , and Backfill‐SMB strategies, (c) FeedCol strategy . Solid line: extract; dashed line: raffinate.…”