The level of economic security is assessed on the basis of resource, labor, financial, innovation, investment, budgetary and regional security, which together represent the socio-economic security or socio-economic potential of the regions. In the study, the regions of Russia are ranked by the level of economic security on the basis of the selected group of indicators for assessing the socio-economic potential of the regions. The tests carried out by Mann-Whitney, Fligner-Keelin, and split testing allowed us to conclude that the selected regional groups in terms of economic security are heterogeneous, that is, the distribution of indicators in groups and their mean values differ significantly. An adequate logit model has been formed, which makes it possible to predict the class of economic security of a region. The receiver operating characteristic has been constructed, and the quality of the model has been assessed by calculating the area under the curve. The key indicators of economic security are determined by the method of principal components.