Optimization of sulfation of okra fruit gum for improved rheological and pharmacological properties

Nagpal, Meenu; Kaur, Manjot; Sharma, Deepika; Baldi, Ashish; Chandra, Ramesh; Madan, Jitender

doi:10.1016/j.ijbiomac.2018.10.155

Cited by 17 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, to prepare sulfated derivatives with higher activity, orthogonal experiments, and response surface methodology (RSM) are usually used to optimize the preparation conditions of polysaccharides derivatives. [32][33][34] Nagpal et al [35] used CSA/Pyr reagent to synthesize sulfated derivatives of okra pectin with the DS ranging from 0.39 to 1.13, and optimized the reaction conditions via Box-Behnken Design (BBD) of RSM. The results show that the optimum reaction conditions of sulfated okra pectin were as follows: CSA/Pyr ratio of 0.28 and reaction time of 3.05 h. Compared with unmodified okra pectin, sulfated okra pectin has significantly enhanced anticoagulant and antimicrobial properties.…”

Section: Chlorosulfonic Acid Pyridine Methodsmentioning

confidence: 99%

“…Currently, increasing studies on structure-activity relationship mainly focused on the different DS of sulfated polysaccharides. [35] A large number of studies have confirmed that sulfated polysaccharides with higher DS have better biological activities. [25,27] Polysaccharides with high DS combine more sulfated groups than polysaccharides with low DS.…”

Section: Dsmentioning

confidence: 99%

See 1 more Smart Citation

Modification, Structural Characterizations, and Biological Activities of Sulfated Polysaccharides: A Review

Hao,

Dai,

Tan

et al. 2023

Starch Stärke

View full text Add to dashboard Cite

Polysaccharides are another important class of bioactive macromolecules in organisms, in addition to proteins and nucleic acids. Numerous studies have confirmed that polysaccharides have various biological activities, including anti‐inflammatory, antiviral, antioxidant, immunomodulatory, anticancer, and other activities, which have attracted the attention of researchers in the biomedical field. In the past decade, increasing researches have found that sulfation modification can improve many physicochemical properties of polysaccharides, significantly enhance their original biological activities, and even generate new activity. Hence, sulfated polysaccharides have attracted more and more attention. A systematic review of the latest research progress and future development prospects of sulfated polysaccharides is very essential to better understand them. Hence, the study has systematically summarized current knowledge about synthesis, structural characteristics, biological activities, and potential molecular mechanisms of sulfated polysaccharides. This review provides some valuable insights and important guidance for the further study of sulfated polysaccharides.

show abstract

Section: Chlorosulfonic Acid Pyridine Methodsmentioning

confidence: 99%

Section: Dsmentioning

confidence: 99%

Modification, Structural Characterizations, and Biological Activities of Sulfated Polysaccharides: A Review

Hao,

Dai,

Tan

et al. 2023

Starch Stärke

View full text Add to dashboard Cite

show abstract

The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics

et al. 2021

View full text Add to dashboard Cite

Neurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brain stimulation, large, stiff, and battery powered neural probes recruit thousands of neurons with each pulse, and can invoke a vigorous immune response. This paper presents challenges in engineering and neuroscience in developing miniaturized and biointegrated alternatives, in the form of microelectrode probes. Progress in design and topology of neural implants has shifted the goal post toward highly specific recording and stimulation, targeting small groups of neurons and reducing the foreign body response with biomimetic design principles. Implantable device design recommendations, fabrication techniques, and clinical evaluation of the impact flexible, integrated probes will have on the treatment of neurological disorders are provided in this report. The choice of biocompatible material dictates fabrication techniques as novel methods reduce the complexity of manufacture. Wireless power, the final hurdle to truly implantable neural interfaces, is discussed. These aspects are the driving force behind continued research: significant breakthroughs in any one of these areas will revolutionize the treatment of neurological disorders.

show abstract

Synthesis of tailor-made polysaccharides: An overview

Al-Muhanna

Anwar

Hasnain³

et al. 2023

Tailor-Made Polysaccharides in Drug Delivery

View full text Add to dashboard Cite

Optimization of sulfation of okra fruit gum for improved rheological and pharmacological properties

Cited by 17 publications

References 25 publications

Modification, Structural Characterizations, and Biological Activities of Sulfated Polysaccharides: A Review

Modification, Structural Characterizations, and Biological Activities of Sulfated Polysaccharides: A Review

The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics

Synthesis of tailor-made polysaccharides: An overview

Contact Info

Product

Resources

About