Optimization of the Crystallization Process of Bis(2‐hydroxyethyl) Terephthalate

Yuan, Peiquan; Liu, Bao‐Shu; Sun, Hua

doi:10.1002/crat.202100025

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Both conversion and yield values from experiment R-VII reasonably fell in the reported conversion range of 50 to 100% and yield range of 55 to 90%, respectively. − , If necessary, the actual crystal yield of BHET monomers can further be increased by cooling the filtrate to 4 °C to recover more dissolved BHET monomers, as shown later in experiment C-I in Table S1. These purity values are comparable with that of a previous investigation of 98.86% . If a higher purity of BHET monomers than our current value of 98.5 ± 0.0% is desired, it may be easily achieved by recrystallization in water at the expense of reduced crystal yield of BHET monomers.…”

Section: Resultssupporting

confidence: 86%

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Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water

Lee,

Peng,

Lee

et al. 2023

Ind. Eng. Chem. Res.

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A systematic study was carried out to develop the cooling crystallization of bis(2-hydroxyethyl) terephthalate (BHET) from 65 to 25 °C with various cooling rates (5 and 80 °C/h) and volumes of water added (60, 120, and 240 mL) after fixing the glycolysis conditions for 10 g clear poly(ethylene terephthalate) (PET) in 60 mL of ethylene glycol (EG) (T = 185 °C, t = 2 h, and catalyst = 0.111 g Na2CO3). The glycolysis of PET gave the actual conversion, crystal yield, and purity of BHET monomers of 93.0 ± 0.7, 70.3 ± 1.5, and 98.5 ± 0.0%, respectively. The use of water as the solvent medium was found to be advantageous for impurity and catalyst removal. The increase in water volume affected the actual conversion and purity insignificantly but decreased the viscosity of the H2O/EG solution, which gave faster nucleation rates favoring the production of the 180–250 μm-sized metastable δ-form BHET needle-like crystals with less crystal yield, shorter filtration and drying times, and poor flowability. The concept of carrying out glycolysis on the recycled BHET dimers was also successfully verified.

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Section: Resultssupporting

confidence: 86%

“…These purity values are comparable with that of a previous investigation of 98.86%. 39 If a higher purity of BHET monomers than our current value of 98.5 ± 0.0% is desired, it may be easily achieved by recrystallization 40 in water at the expense of reduced crystal yield of BHET monomers.…”

Section: Glycolysis Of Pet and Cooling Crystallization Of Bhet Monome...mentioning

confidence: 88%

Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water

Lee,

Peng,

Lee

et al. 2023

Ind. Eng. Chem. Res.

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“…Thus, further engineering of Kubu-P M12 for higher EG tolerance would allow glycolysis reactions to occur at higher temperatures, enhancing both its depolymerization rate and degree. This may also act as a starting point for the development of a BHET recovery process based on cooling crystallization ( 36 ), by producing BHET at concentrations sufficient to form crystalline nuclei at low temperatures (fig. S26).…”

Section: Discussionmentioning

confidence: 99%

Landscape profiling of PET depolymerases using a natural sequence cluster framework

Seo,

Hong,

Park

et al. 2024

Preprint

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Since the demonstration that rapid polyethylene terephthalate (PET) decomposition using enzymes is feasible, a number of efficient depolymerases have been reported with the aim of resolving the plastic pollution issues. However, sporadic studies on enzymes with PET hydrolysis activity hinder the understanding of the distribution of potential PETases hidden in nature’s repertoire, and subsequently, the identification of potent enzymes. Here, we present the clustering of 1,894 PETase candidates, which include the majority of known PETases, and describe their profiling. An archipelago landscape of 170 lineages shows distribution of 289 representative sequences with features associated with PET-degrading capabilities. A bird’s-eye view of the landscape identifies three highly promising yet unexplored PETase lineages and two potent PETases, Mipa-P and Kubu-P. The engineered Mipa-PM19and Kubu-PM12variants exhibit both high PET hydrolysis activity and thermal stability. In particular, Kubu-PM12outperformed the engineered benchmarks in terms of PET depolymerization in harsh environments, such as with high substrate load and ethylene glycol as the solvent. Our landscape framework and the identified variants assist in the understanding of how biological processes respond to solid-state and non-natural PET plastics.

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“…Hence, the desired shape will change according to different product demand. − Particles with larger size usually have high bulk density, which is conducive to product packaging . Smaller particles are favored for insoluble drugs because they have faster dissolution rate. , By controlling the crystal size, sustained or controlled release of the drug can be achieved, and the speed and dose of the drug can be precisely controlled in the body, so that the concentration of the drug is kept stable within the therapeutic range . Therefore, it is of great significance to regulating crystal morphology in the crystallization process …”

Section: Introductionmentioning

confidence: 99%

Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals

Pan,

Cao,

et al. 2024

ACS Omega

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The effect of surfactant, polymer, and tailor-made additives on the crystallization of γ-aminobutyric acid (GABA) was studied in this work. Cooling crystallization of GABA in water yielded plate-like crystals. In the presence of sodium stearate, polyhedral block-like crystals of GABA were obtained. Hydroxyethyl cellulose (HEC) led to rod-like crystals, in which the morphology was associated with additive concentrations. Six kinds of amino acids were used as tailor-made additives, and they exhibit different influences on crystal shape and size. The induction time of GABA was determined in the absence and presence of additives. The results showed that sodium stearate promoted nucleation, while HEC, L-Lysine, L-histidine, and L-tyrosine inhibited nucleation. Crystal face indexing, Hirshfeld surface analysis, and molecular dynamics (MD) simulation in aqueous solution−crystal systems were carried out to investigate the affecting factors of different crystal faces. The polymer additive was selected as an example during MD simulation to calculate intermolecular interactions between the crystal face and solvent or additive. The effect of the additive on the mobility of the solute in solution was also evaluated by mean-square displacement. The additive offers an effective approach for changing crystal morphology and particle size and adapting it to different production requirements.

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Optimization of the Crystallization Process of Bis(2‐hydroxyethyl) Terephthalate

Cited by 7 publications

References 29 publications

Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water

Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water

Landscape profiling of PET depolymerases using a natural sequence cluster framework

Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals

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