2022
DOI: 10.1016/j.heliyon.2021.e08682
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Optimization of ultrasonic-assisted extraction of polyphenols from the polyherbal formulation of Cinnamomum verum, Origanum majorana, and Origanum vulgare and their anti-diabetic capacity in zebrafish (Danio rerio)

Abstract: The Cinnamomum verum (CV) , Origanum majorana (CM), and Origanum vulgare (OV) have been used in traditional medicine in several regions of México for their anti-diabetic properties. In this study investigated the variables of ultrasound-assisted extraction for the polyphenolic compounds from the combination of these plants and explore their potential antidiabetic activities on glucose-induced-diabetic zebrafish. Determined the optimum conditi… Show more

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Cited by 17 publications
(5 citation statements)
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“…Ten grams of polyherbal formulation powder was placed in a capped tube and subjected to UAE using an ultrasonic cleaning bath (KH5200 DB type, Kunshan ultrasonic instrument Co., Ltd., Kunshan, China). The process was carried out using a frequency of 40 kHz and at 200 W with the following optimal extraction conditions: ethanol 66.03%, 28.87 min, and 21.51 mL/g for maximal flavonoids extraction [ 49 ]. After we collected the supernatant using UAE, the samples were centrifuged at 5000 rpm for 10 min and UV–Vis analyses were performed at 360 nm.…”
Section: Methodsmentioning
confidence: 99%
“…Ten grams of polyherbal formulation powder was placed in a capped tube and subjected to UAE using an ultrasonic cleaning bath (KH5200 DB type, Kunshan ultrasonic instrument Co., Ltd., Kunshan, China). The process was carried out using a frequency of 40 kHz and at 200 W with the following optimal extraction conditions: ethanol 66.03%, 28.87 min, and 21.51 mL/g for maximal flavonoids extraction [ 49 ]. After we collected the supernatant using UAE, the samples were centrifuged at 5000 rpm for 10 min and UV–Vis analyses were performed at 360 nm.…”
Section: Methodsmentioning
confidence: 99%
“…Blood glucose, cholesterol and triglyceride levels were reduced in diabetic zebrafish induced by exposure to a 110 mM concentration of glucose following exposure to the extract of Cinnamomum verum, Origanum majorana and Origanum vulgare, while exposure to the polyherbs formed from these three extracts together induced a significant reduction in hyperglycemia and hyperlipidemia [19].…”
Section: Animal Modelmentioning
confidence: 96%
“…This might be due to the fact that the polarity of the 60% ethanol was the closest to that of the paeonol, which rendered the paeonol more easily dissolvable [53]. According to the similarity and compatibility [54], when the polarity of the paeonol was similar to that of the ethanol solution, the solubility of paeonol was the highest. When the ethanol concentration was below 60%, the polarity of the ethanol solution increases, leading to decrease in the dissolution of paeonol, while when the ethanol concentration was greater than 60%, the polarity of the ethanol solution decreases, which was not conducive to the dissolution of paeonol.…”
Section: Effects Of the Various Factors On The Extraction Yield Of Th...mentioning
confidence: 99%