Optimization of Ultrasound‐Assisted Extraction of Monoterpene Glycoside from Oil Peony Seed Cake

Abstract

Ultrasound-assisted extraction (UAE) of total monoterpene glycosides extract (TMGE) from oil peony seed cakes was investigated. The extraction yield was optimized using response surface methodology (RSM). The chemical constituents of the monoterpene glycosides extract were isolated by repeated column chromatography, and the contents of the main isolated monoterpene glycosides in the oil peony seed cakes were determined by HPLC. The optimum conditions were as follows: a liquid-to-solid ratio of 27 mL/g, ultrasonic extraction time of 16 min, ultrasonic extraction temperature of 26°C, and ethanol concentration of 67%. Under these conditions, the extraction yield of TMGE was 10.24%. Twenty monoterpene glycosides were isolated from the oil peony seed cakes, and compounds 11-12, 16 and 20 showed strong inhibitory activities on NO production. TMGE from oil peony seed cakes can also to be used as promising immunosuppressive drug due to its high content of monoterpene glycosides and immune-inhibitory activity.Practical Aapplication: The peony seed oil was authorized as a new food by the Ministry of Health of the People's Republic of China. Peony seed cake is one of the most important by-products in the preparation of peony seed oil, and accounts for approximately 40% of the total mass of the peony seed. Total monoterpene glycosides are the main active ingredient of oil peony seed cake. This research has optimized the extraction conditions of total monoterpene glycoside from seeds cake of Paeonia ostii, which will provide useful reference information for further studies, and offer related industries with helpful guidance in practice.

Characterization of Agronomic and Seed Oil Features for Different Cultivars of Tree Peony

“…The oil content of 29 cultivars was significantly higher than 'Fengdan' (20.87 ± 0.26%) and 'Zibanbai' (21.24 ± 1.00%) (p < 0.05). Most of the cultivars have oil content of more than 20%, which is consistent with the literature [39,40]. This shows that other tree peony cultivars also have the potential for oil use.…”

Integrated Profiling of Fatty Acids, Sterols and Phenolic Compounds in Tree and Herbaceous Peony Seed Oils: Marker Screening for New Resources of Vegetable Oil

“…Due to the same source, the flowers and seeds of the tree peony also contained phenolic compounds [7,8]. Even the extraction of monoterpene glycoside from the oil-extracted residues of tree peony seeds was investigated [9]. As for tree peony seed oil, there is no report about the phenolic compounds at present.…”

Study on immunoregulation function of peony seed proteolysis product in mice

“…As a by‐product of Cortex Moutan, the oil content of peony seeds can be as high as 23.76%–27.06%. Peony seeds are rich in monoterpene glycosides, linoleic, and other unsaturated fatty acids, which makes it highly sought after (Deng et al., 2018; Liu et al., 2017; Liu, Zhang, Gao, Du, & Zhang, 2018, Liu, Zhang, Gao, Du, & Zhang, 2018; Liu, Zhang, Xu, Zhu, & Xu, 2018). The peony seed meal remaining after oil extraction has relatively few uses and is often used as feed for livestock and poultry breeding.…”