Optimization of ultrasound-assisted extraction of astaxanthin from black tiger shrimp (Penaeus monodon) shells using deep eutectic solvent and ethanol as a co-solvent

Hai, Tran Chi; Van Man, Phan; Hong Anh, Le Thi

doi:10.1016/j.lwt.2024.116965

LWT

2024

DOI: 10.1016/j.lwt.2024.116965

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Optimization of ultrasound-assisted extraction of astaxanthin from black tiger shrimp (Penaeus monodon) shells using deep eutectic solvent and ethanol as a co-solvent

Tran Chi Hai,

Phan Van Man,

Le Thi Hong Anh

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2024

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Cited by 1 publication

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Bioactive Molecules from the Exoskeleton of Procambarus clarkii: Reducing Capacity, Radical Scavenger, and Antitumor and Anti-Inflammatory Activities

Longo,

Di Gaudio,

Attanzio

et al. 2024

Biomolecules

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This study evaluates, for the first time, the reducing capacity, radical scavenger activity, and in vitro antitumor and anti-inflammatory effects of chitosan, astaxanthin, and bio-phenols extracted from the exoskeleton of Sicilian Procambarus clarkii, the most widespread species of invasive crayfish in the Mediterranean region. Among the extracted compounds, astaxanthin exhibited the highest antioxidant activity in all assays. Chitosan and polyphenols demonstrated reducing and radical scavenging activity; chitosan showed significant ferric ion reducing capacity in the FRAP test, while bio-phenolic compounds displayed notable radical scavenging activity in the DPPH and ABTS assays. Both astaxanthin and polyphenols showed dose-dependent cytotoxicity on two different cancer cell lines, with IC50 values of 1.45 µg/mL (phenolic extract) and 4.28 µg/mL (astaxanthin extract) for HepG2 cells and 2.45 µg/mL (phenolic extract) and 4.57 µg/mL (astaxanthin extract) for CaCo-2 cells. The bio-phenolic extract also showed potential anti-inflammatory effects in vitro by inhibiting nitric oxide production in inflamed RAW 264.7 macrophages, reducing the treated/control NO ratio to 77% and 74% at concentrations of 1.25 and 1.5 μg/mL, respectively. These results suggest that P. clarkii exoskeletons could be a valuable source of bioactive molecules for biomedical, pharmaceutical, and nutraceutical application while contributing to the sustainable management of this invasive species.

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Bioactive Molecules from the Exoskeleton of Procambarus clarkii: Reducing Capacity, Radical Scavenger, and Antitumor and Anti-Inflammatory Activities

Longo,

Di Gaudio,

Attanzio

et al. 2024

Biomolecules

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show abstract

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Optimization of ultrasound-assisted extraction of astaxanthin from black tiger shrimp (Penaeus monodon) shells using deep eutectic solvent and ethanol as a co-solvent

Cited by 1 publication

References 25 publications

Bioactive Molecules from the Exoskeleton of Procambarus clarkii: Reducing Capacity, Radical Scavenger, and Antitumor and Anti-Inflammatory Activities

Bioactive Molecules from the Exoskeleton of Procambarus clarkii: Reducing Capacity, Radical Scavenger, and Antitumor and Anti-Inflammatory Activities

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