Optimization of vanadium oxide catalyst for the oxidation of 3-methylpyridine into nicotinic acid

Vorobyev, P. B.; Mikhailovskaya, T. P.; Yugay, O. K.; Saurambaeva, L. I.; Serebryanskaya, A. P.; Chukhno, Nikolay; Kurmakyzy, R.

doi:10.2298/jsc161220023z

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…A green alternative to the harsh Lowry-Bronsted acidic method is using mild Lewis acid. An oxidation method that employs V 2 O 5 and TiO 2 is found to oxidize 3-methyl pyridine into nicotinic acid [34].…”

Section: Uses In Various Organic Reactionsmentioning

confidence: 99%

Developments and uses of Lewis acids: from conventional catalysts to modern green catalysts

Mamari¹

2023

Electrophile and Lewis Acid [Working Title]

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Lewis acids have played pivotal role in organic synthesis. The inherent Lewis acidity of semi-metal or metal ions, which stems from possession of empty orbitals or electron-accepting ability/electron pair affinity, has granted them ability to catalyze various and numerous organic functional group transformations and methods for carbon-carbon (C-C) bond formation reactions. Lewis acids have developed from conventional catalysts to modern green ones that have enabled a wide range of chemical transformations and chemical processes of applications in various fields such as pharmaceutical and petroleum/petrochemical industries. The chapter begins with definition and description of Lewis acids and their significance in chemistry as an electronic science. The chapter then covers uses and applications of Lewis acids as homogeneous catalysts in conventional organic reactions that employ and/or are Lewis-acids catalysts. Coverage continues on the importance of developments and inception of green and environmentally benign Lewis acids that can help preserve the environment, in a manifestation of green chemistry principles. Illustrations of the importance and applications of green Lewis acids in Lewis acid-catalyzed organic reactions and C-C bond formation reactions are covered. The chapter aims at introducing and stimulating the reader to Lewis acids, their description and significance in synthetic organic chemistry in particular and in chemistry as a whole.

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Section: Uses In Various Organic Reactionsmentioning

confidence: 99%

Developments and uses of Lewis acids: from conventional catalysts to modern green catalysts

Mamari¹

2023

Electrophile and Lewis Acid [Working Title]

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“…Researchers at the Bekturov Institute of Chemical Sciences have studied the effect of Al 2 O 3 , SnO 2 , and ZrO 2 additives to vanadium catalysts [69,70]. Tests at 300 • C for a 1:1 ratio of V 2 O 5 :Al 2 O 3 obtained NA with 64% efficiency and 94% selectivity, while a 2:1 ratio obtained NA with only 47% efficiency but almost 96% selectivity [69].…”

Section: Oxidation Of 3-methylpyridine In the Gas Phasementioning

confidence: 99%

“…Tests at 300 • C for a 1:1 ratio of V 2 O 5 :Al 2 O 3 obtained NA with 64% efficiency and 94% selectivity, while a 2:1 ratio obtained NA with only 47% efficiency but almost 96% selectivity [69]. The institute also carried out a pilot-scale study, which showed greater activity and more favorable results using the V 2 O 5 -ZrO 2 -TiO 2 system as opposed to V 2 O 5 -SnO 2 -TiO 2 , and NA was obtained with 75-77% efficiency and 90% selectivity [70].…”

Section: Oxidation Of 3-methylpyridine In the Gas Phasementioning

confidence: 99%

Methods to Produce Nicotinic Acid with Potential Industrial Applications

2022

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Nicotinic acid is a naturally occurring pyridine carboxylic acid, contained in vitamin PP, an essential nutrient for humans and animals, and used as an antipelagic agent. Nicotinic acid can be made from tryptophan by plants and animals but is usually not completely bioavailable. Industrially, nicotinic acid is produced mainly by oxidation of 5-ethyl-2-methylpyridine with nitric acid. One of the by-products of the process is nitrous oxide, a gas that is difficult to recycle and manage, with a greenhouse effect 300 times stronger than CO2. A new technology for the industrial production of nicotinic acid is undoubtedly necessary to meet the needs of green chemistry and not burden the environment. We carried out a literature review on ecological methods to produce nicotinic acid from commercially available raw materials such as 3-methylpyridine and 5-ethyl-2-methylpyridine, especially focusing on those methods with potential industrial applications.

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“…The products of deep oxidation were analyzed by a gas chromatographic method with a thermal conductivity detector. 10…”

Section: Analysis Of 34-dimethylpyridine Ammoxidation Productsmentioning

confidence: 99%

“…The description of quantum chemical calculations is given in the previous article. 10 Optimization of the geometry of the organic molecules and carbanions in the gaseous phase was carried out by the ab initio method (HF/6-31G*). Modeling of chemisorption was carried by the density functional theory method, 11 using a two-exponent basic set LanL2DZ with an effective core potential.…”

Section: Computing Details Of Quantum-chemical Modelingmentioning

confidence: 99%

Oxidative ammonolysis of 3,4-dimethylpyridine on the vanadium oxide catalysts

Vorobyev¹,

Serebryanskaya²,

Yugay³

et al. 2020

JSCS

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Oxidative ammonolysis of 3,4-dimethylpyridine on an individual vanadium oxide (V 2 O 5 ) catalyst and binary vanadium oxide catalysts, modified by additions of SnO 2 and ZrO 2 , has been studied. A connection between СНacidity of the methyl groups of the substrate in the gaseous phase and in the chemosorbed state and the sequence of their transformation into a cyano group has been established. It has been shown that nucleophilicity of vanadyl oxygen, calculated by the Density Functional Theory method, increases with V 2 O 5 modification by SnO 2 and ZrO 2 additions. Herewith, an increasing yield of 3methyl-4-cyanopyridine and imide of pyridine-3,4-dicarboxylic acid was observed. A proposed mechanism of the imide of pyridine-3,4-dicarboxylic acid formation has been discussed

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Optimization of vanadium oxide catalyst for the oxidation of 3-methylpyridine into nicotinic acid

Cited by 4 publications

References 11 publications

Developments and uses of Lewis acids: from conventional catalysts to modern green catalysts

Developments and uses of Lewis acids: from conventional catalysts to modern green catalysts

Methods to Produce Nicotinic Acid with Potential Industrial Applications

Oxidative ammonolysis of 3,4-dimethylpyridine on the vanadium oxide catalysts

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