Optimization of vasomotor and neuropsychiatric disorders treatment in climacteric syndrome

Horbatiuk, О. H.; Григоренко, А. П.; Shatkovska, A.S.; Binkovska, Alla; Onyshko, V. Yu.; Gerich, Ottokar

doi:10.14739/2310-1210.2017.4.105110

Cited by 2 publications

(5 citation statements)

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“…No significant increase in progesterone was observed. These indicators are correlated with the data of many researchers [4,5,6,7].…”

Section: Discussionmentioning

confidence: 99%

“…The problem of disorders in the hormone-dependent organs and systems of the body of the woman during the period of perimenopause and post-menopause is becoming more urgent, since it is primarily concerned with the quality of life of women during their professional maturity and the greatest activity in family and public life [6,7,15,19].…”

Section: Introductionmentioning

confidence: 99%

“…An analysis of the age structure of the population in recent years shows that Ukraine is in a state of deep demographic crisis caused by depopulation, an increase in the share of elderly people, and a decrease in the average life expectancy [7,18,19]. This has a negative impact on the development of productive forces, the level of well-being of people and the economic situation in the country [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…According to WHO, 46 % of women are now over the age of 45 (peri and post-menopausal) on the planet already, among women of Ukraine it is 13.2 million, that is almost half [5,18,19], therefore the increase in life expectancy and prolongation age of working capacity is gaining not only medical but also socio-economic importance, both in Ukraine and in other European countries. Systemic irreversible changes that develop in the body of a woman during menopause due to progressive estrogen deficiency [7,12,13,14,17], dictate the need to find effective methods for their prediction, as well as the introduction of alternative methods of prevention and treatment of menopausal disorders [4,7,11,18].…”

Section: Introductionmentioning

confidence: 99%

“…The gradual involution of the ovarian parenchyma is accompanied by a decrease in the production of sex hormones (estradiol, progesterone and androgens) [1,3,16]. Due to the fact that hormonal regulation in the body occurs on the principle of feedback, due to the decreased level of estrogen in the pituitary gland, there is an increase in the production and release of gonadotropic hormones [2,4,7,10].…”

Section: Introductionmentioning

confidence: 99%

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Peculiarities of hormonal homeostasis in perimenopausal and postmenopausal women with menopausal disorders

Vaskiv¹,

Григоренко²,

Horbatiuk³

et al. 2019

Biomed. and Biosoc. Anthrop.

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According to WHO, now on the planet 46% of women are over the age of 45 years, among women in Ukraine – this is almost half (13.2 million). Of these, 46-68% suffer from climacteric syndrome. An increase in the duration of a healthy life and prolongation of the age of working capacity acquire not only medical, but also socio-economic significance, both in Ukraine and in other European countries. Therefore, the aim of the study was a comprehensive (involving pituitary, ovarian, adrenal and thyroid hormones) hormonal examination of women of peri- and postmenopausal age with menopause syndrome to identify the most likely hormonal predictors of this pathology. For this purpose, 64 women of perimenopausal and postmenopausal age with menopause and 42 healthy women of the same age categories had a study of the concentration of pituitary (LH, FSH, prolactin), ovarian hormones (estradiol, progesterone, testosterone), thyroid hormones (TSH, triiodothyronine (T3), thyroxine (T4)) and adrenal glands (DHEA-s, cortisol) in blood plasma. Hormones were determined using a set of test systems from “Immunotech” (Czech Republic-France) using the radio-immune method. Comparisons of the quantitative data of the two related groups (before and after treatment) were made using Wilcoxon signed rank test. When differences were detected, pairwise group comparisons were performed using the Mann-Whitney test. In women of perimenopausal and postmenopausal age with menopause syndrome, compared with healthy women of the same age groups, a significant increase in gonadotropin levels (LH by 3.7 and 3.0 times, respectively; FSH by 1.6 and 1.9 times) and a decrease indicator of prolactin in 1.5 and 1.2 times; estradiol 1.2 and 2.2 times and testosterone 2.9 and 2.4 times. A significant decrease in progesterone by 1.9 times occurred only in the group of postmenopausal women with menopause syndrome. In women of perimenopausal and postmenopausal age of the main group, a significant decrease was found in comparison with the control of DHEA-s levels by 1.3 times and 2.2 times, respectively; cortisol 1.2 and 2.0 times; TSH is 2.6 times and 2.0 times, respectively, however, thyroxine tended to increase (the probability p<0.05 was valid only for women of perimenopausal age). Thus, in postmenopausal women with menopausal syndrome, hormonal imbalance is more pronounced, indicating a deep atrophy of hormone-dependent tissue receptors and, as a result, a deepening of involutive processes.

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“…No significant increase in progesterone was observed. These indicators are correlated with the data of many researchers [4,5,6,7].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%