Aiming at the problems of high energy consumption and particle breakage in the pneumatic conveying process of large-scale breeding enterprises, in this paper, based on the theoretical calculated value of particle suspension velocity, a computational fluid model and a discrete element model are established based on computational fluid dynamics (CFD) and discrete element method (DEM). Then, through the numerical simulation of gas-solid two-phase flow, the influence of four factors of conveying wind speed, particle mass flow rate, pipe diameter, and particle size on the velocity distribution of particles in a horizontal pipe, dynamic pressure change in the pipe, pressure drop in the pipe, and solid mass concentration are studied. The results show that the k-ε turbulence model can better simulate the movement of gas-solid two-phase flow, and through the analysis of the simulation, the influence of four different factors on the conveying characteristics is obtained, which provides a scientific basis for the construction of the conveying line.