1980
DOI: 10.1007/bf00504483
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Optimization of whey fermentation in a jar fermenter

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1981
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Cited by 24 publications
(6 citation statements)
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“…In particular, it was shown that a feed scheme using lactose concentrations greater than 30 g dm-3 results in lower biomass yields and greater accumulation of metabolic products, while with feed concentrations of lactose as low as 1 5 g d m -3 it is easier to satisfy the microbial oxygen demand rate and minimise the aforementioned inhibitory effect, thus confirming previous results performed batchwise in a laboratory-fermenter under similar oxygen transfer rates. 4 In conclusion, since the lactose feed scheme was found to be of crucial importance in obtaining high biomass yields, such a mathematical model might be used to optimise the feed scheme and oxygen transfer on the assumption that cell growth is limited by neither oxygen nor nitrogen availability and controlled by lactose level only, by carrying out a cost/benefit analysis aimed at minimising yeast production …”
Section: Discussionmentioning
confidence: 99%
“…In particular, it was shown that a feed scheme using lactose concentrations greater than 30 g dm-3 results in lower biomass yields and greater accumulation of metabolic products, while with feed concentrations of lactose as low as 1 5 g d m -3 it is easier to satisfy the microbial oxygen demand rate and minimise the aforementioned inhibitory effect, thus confirming previous results performed batchwise in a laboratory-fermenter under similar oxygen transfer rates. 4 In conclusion, since the lactose feed scheme was found to be of crucial importance in obtaining high biomass yields, such a mathematical model might be used to optimise the feed scheme and oxygen transfer on the assumption that cell growth is limited by neither oxygen nor nitrogen availability and controlled by lactose level only, by carrying out a cost/benefit analysis aimed at minimising yeast production …”
Section: Discussionmentioning
confidence: 99%
“…RSM is suitable for identifying the effect of individual variables and for efficiently seeking the conditions for an optimum response in a multivariable system (Montgomery, 2001). This method has been successfully applied to optimize fermentation processes (Maddox and Reichert, 1997;Chen, 1981;Grothe et al, 1999;Ratnam et al, 2003;Casas López et al, 2004), vegetable oil bioconversion (Cheynier et al, 1983), biomass production (Moresi et al, 1980), and numerous other processes (Panda et al, 1999;Ellaiah et al, 2002;Adinarayaan and Suren, 2005). Effects of temperature, pH, and enzyme dosage on sago starch hydrolysis using bacterial a-amylase, b-glucanase, and pullulanase have been previously studied using statistical design of experiment (Gorinstein et al, 1994).…”
Section: Introductionmentioning
confidence: 96%
“…It aids the process by identifying the effect of individual variables and thus seeking the optimum conditions for them. RSM has displayed successful applications in various processes like optimisation of alcoholic fermentation , optimisation of vegetable oil bioconversion , biomass production and enhancement of enzyme production . The RSM design applies the central composite rotatable design (CCRD) and estimation of coefficients for a model equation is one of its applications.…”
Section: Introductionmentioning
confidence: 99%