To investigate the mechanical behavior and design methodology of column-free QRST (quasi-rectangular segmental tunnel) structures, a theoretical analysis based on prototype experiments and simulation models is conducted. Initially, a prototype experimental investigation is conducted to reveal the structural behavior at the service stage. Subsequently, the ESHR model (Equivalent Stiffness Homogeneous Ring), the BS model (Beam Spring), and the MBS model (Modified Beam Spring) are used to simulate structural behavior. For design purposes, the design methodology is explored based on the ESHR model, followed by a sensitivity analysis of several key load parameters. Based on the experimental results, weak parts of the column-free QRST structure are found to include several joints (Joint 1, Joint 5, Joint 3, and Joint 8), and corresponding optimization measures are proposed. By comparing the test results, the above-mentioned three models demonstrate their applicability in structural simulation, with the ESHR model having sufficient design accuracy. A model-based deformation mechanism analysis found that joints contribute approximately 2/3 of the structural deformation. For the structural design of the column-free QRST using the ESHR model, amplifying the calculated results of structures directly subjected to the service stage by 10% suffices to meet engineering requirements. Based on the test and study, special attention should be paid to the negative bending moment regions at the waists of the structure during both the design and service stages.