Optimized auditory transcranial alternating current stimulation improves individual auditory temporal resolution

Baltus, Alina; Wagner, Sven; Wolters, Carsten H.; Herrmann, Christoph S.

doi:10.1016/j.brs.2017.10.008

Cited by 48 publications

(79 citation statements)

References 36 publications

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“…This is because tDCS effect depends on the interaction between the induced tissue current, the geometry of the neural structures and the cortical folding pattern. While such effects are well known and predictable for the sensory‐motor cortex, they are largely unknown for stimulation of other brain areas (Landi et al, ; Baltus, Wagner, Wolters, & Herrmann, ; Jacobson, Koslowsky, & Lavidor, ; Joos, De Ridder, Van de Heyning, & Vanneste, ; Lorenz, Müller, Schlee, Langguth, & Weisz, ; Prete, D'Anselmo, Tommasi, & Brancucci, ).…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Pellegrino

Arcara

Pino

et al. 2019

Human Brain Mapping

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Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham‐controlled, double‐blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory‐motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro‐temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

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Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Pellegrino

Arcara

Pino

et al. 2019

Human Brain Mapping

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“…In Baltus et al. () an optimized stimulation electrode setup specifically suitable for auditory tACS was introduced (Figure ). With this setup, we demonstrated a frequency‐specific effect of auditory tACS on auditory temporal resolution in normal hearing adults.…”

Section: Methodsmentioning

confidence: 99%

“…Recent research provides evidence for a physiological relevance of the IGF for auditory processing in terms of an established correlation between individually determined IGFs and individually determined gap detection thresholds in a between‐channel gap detection task (Baltus & Herrmann, ). The purely correlational link was supported by a second study where an application of frequency‐specific auditory transcranial alternating current stimulation (tACS) during execution of the same between‐channel gap detection task led to a frequency‐specific modulation of gap detection thresholds on an individual level (Baltus et al., ). Applying tACS is assumed to modulate ongoing neuronal oscillations in targeted areas by shifting the frequency of the oscillation away from the eigenfrequency (Herrmann, Rach, Neuling, & Strüber, ; Thut, Schyns, & Gross, ).…”

Section: Introductionmentioning

confidence: 97%

“…A large body of evidence supports the idea of a decisive role of ongoing gamma band oscillations (30–70 Hz) in auditory cortex areas for auditory processing (Brosch, Budinger, & Scheich, ; Cervenka et al., ; Lakatos et al., ; Schadow et al., ; Traub, Bibbig, LeBeau, Cunningham, & Whittington, ). Recent research provides evidence for the assumption that not only different frequency bands can be associated with different perceptual processes but also frequency differences within the gamma band are physiologically relevant on an individual basis (Baltus & Herrmann, , ; Baltus et al., ; Zaehle, Lenz, Ohl, & Herrmann, ). Unlike in vision, in audition, the determination of frequency of relevant neuronal oscillations cannot be estimated from resting state activity but must be derived from indirect measures (Lampl & Yarom, ).…”

Section: Introductionmentioning

confidence: 99%

“…A tACS electrode setup specifically suited to stimulate targets in auditory cortices is introduced in Baltus et al. (). In addition to the electrode locations, the proportions of frequency of the endogenous neuronal oscillation, tACS frequency, and stimulation strength are also crucial if the modulation of the frequency of endogenous neural oscillations is aspired (Notbohm, Kurths, & Herrmann, ).…”

Section: Introductionmentioning

confidence: 99%

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Transcranial alternating current stimulation modulates auditory temporal resolution in elderly people

Baltus

Vosskuhl

Boetzel

et al. 2018

Eur J of Neuroscience

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Recent research provides evidence for a functional role of brain oscillations for perception. For example, auditory temporal resolution seems to be linked to individual gamma frequency of auditory cortex. Individual gamma frequency not only correlates with performance in between-channel gap detection tasks but can be modulated via auditory transcranial alternating current stimulation. Modulation of individual gamma frequency is accompanied by an improvement in gap detection performance. Aging changes electrophysiological frequency components and sensory processing mechanisms. Therefore, we conducted a study to investigate the link between individual gamma frequency and gap detection performance in elderly people using auditory transcranial alternating current stimulation. In a within-subject design, twelve participants were electrically stimulated with two individualized transcranial alternating current stimulation frequencies: 3 Hz above their individual gamma frequency (experimental condition) and 4 Hz below their individual gamma frequency (control condition), while they were performing a between-channel gap detection task. As expected, individual gamma frequencies correlated significantly with gap detection performance at baseline and in the experimental condition, transcranial alternating current stimulation modulated gap detection performance. In the control condition, stimulation did not modulate gap detection performance. In addition, in elderly, the effect of transcranial alternating current stimulation on auditory temporal resolution seems to be dependent on endogenous frequencies in auditory cortex: Elderlies with slower individual gamma frequencies and lower auditory temporal resolution profit from auditory transcranial alternating current stimulation and show increased gap detection performance during stimulation. Our results strongly suggest individualized transcranial alternating current stimulation protocols for successful modulation of performance.

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Characterization of the Somatosensory System

et al. 2021

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Optimized auditory transcranial alternating current stimulation improves individual auditory temporal resolution

Cited by 48 publications

References 36 publications

Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Transcranial alternating current stimulation modulates auditory temporal resolution in elderly people

Characterization of the Somatosensory System

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