Optimized conditions to produce water-in-oil-in-water nanoemulsion and spray-dried nanocapsule of red ginseng extract

Min, Ji-Young; Ahn, Sung‐Il; Lee, Yun-Kyung; Kwak, Hae‐Soo; Chang, Yoon Hyuk

doi:10.1590/fst.09517

Cited by 18 publications

(5 citation statements)

References 31 publications

(37 reference statements)

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“…The drop size distribution of the flavorings is in good agreement with, 41 where MD, WPC, and GA were used to encapsulate red ginseng extract with particle sizes ranging from 100 nm to 3 μm. Also, nano-encapsulated M. piperita using chitosan and Alyssum homolocarpum gum with a particle size distribution range from 490–790 nm demonstrated that the droplet size distribution is consistent across all samples.…”

Section: Resultssupporting

confidence: 73%

Effect of nano-encapsulated food flavorings on streptozotocin-induced diabetic rats

Mohammed,

Abdelgawad,

Ghoneim

et al. 2023

Food Funct.

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Section: Resultssupporting

confidence: 73%

Effect of nano-encapsulated food flavorings on streptozotocin-induced diabetic rats

Mohammed,

Abdelgawad,

Ghoneim

et al. 2023

Food Funct.

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“…According to Gharibzahedi et al (2012), RSM is a collection of useful mathematical and statistical procedures, and it needed to scrutinize multiple factors and their interactions in comparison to other approaches for possessing the advantage of reducing number of experimental trials. Min et al (2018) optimized the nanoencapsulation efficiency with different emulsifiers using RSM in red ginseng extract nanoencapsulation. On the study, the increase of emulsifiers led to nanoencapsulation increase.…”

Section: Optimization Of Conditions For Producing Microemulsion Of Tomentioning

confidence: 99%

Optimization of the conditions for producing water-in-oil-in-water microemulsions and spray-dried microcapsule of tomato extract powder

et al. 2019

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The objective of this study was to investigate optimized conditions for producing water-in-oil-in-water (W/D/W) microemulsions and spray-dried microcapsules of tomato extracts. The condition of highest yield for W/D/W microemulsification was optimized by response surface methodology (RSM). The independent variables were ratio of tomato extract to MCT (X 1 : 1:9-2:8), concentrations of emulsifier (X 2 : 0.50-1.00), and ratio of W/D to secondary aqueous coating material (X 3 : 1:5-1:9). According to the RSM results, the ratio of tomato extract to MCT at 1.24:8.76 (v/v), concentration of emulsifier at 1.00% (w/v), and ratio of W/D phase to secondary aqueous coating material of 1.00:6.16 (v/v) were found to be the optimal conditions for producing microemulsion of tomato extracts. At these conditions, the yield of W/D/W microemulsion determined as approximately 99.69%. After optimizing the conditions for producing microemulsion of tomato extract by RSM, the emulsion was spray-dried. The average particle size (D (4,3)) and zeta-potential value of the spray-dried microcapsules under optimized condition were approximately 5 µm and-29.68 mV, respectively. Results of the present study provide practical information on optimum conditions for producing W/D/W microemulsions and spray-dried microcapsules of tomato extracts.

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“…However, no activity was detected against P. aeruginosa PT3087 (MIC > 500 µL/mL). The observed antibacterial activity against sensitive strains could be related to the ability of some lipids to destabilize the phospholipid membrane of bacterial cells [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Essential Oil and Hydrophilic Antibiotic Co-Encapsulation in Multiple Lipid Nanoparticles: Proof of Concept and In Vitro Activity against Pseudomonas aeruginosa

et al. 2021

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In the worldwide context of an impending emergence of multidrug-resistant bacteria, this research combined the advantages of multiple lipid nanoparticles (MLNs) and the promising therapeutic use of essential oils (EOs) as a strategy to fight the antibiotic resistance of three Pseudomonas aeruginosa strains with different cefepime (FEP) resistance profiles. MLNs were prepared by ultrasonication using glyceryl trioleate (GTO) and glyceryl tristearate (GTS) as a liquid and a solid lipid, respectively. Rosemary EO (REO) was selected as the model EO. REO/FEP-loaded MLNs were characterized by their small size (~110 nm), important encapsulation efficiency, and high physical stability over time (60 days). An assessment of the antimicrobial activity was performed using antimicrobial susceptibility testing assays against selected P. aeruginosa strains. The assays showed a considerable increase in the antibacterial property of REO-loaded MLNs compared with the effect of crude EO, especially against P. aeruginosa ATCC 9027, in which the minimum inhibitory concentration (MIC) value decreased from 80 to 0.6 mg/mL upon encapsulation. Furthermore, the incorporation of FEP in MLNs stabilized the drug without affecting its antipseudomonal activity. Thus, the ability to co-encapsulate an essential oil and a hydrophilic antibiotic into MLN has been successfully proved, opening new possibilities for the treatment of serious antimicrobial infections.

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Optimized conditions to produce water-in-oil-in-water nanoemulsion and spray-dried nanocapsule of red ginseng extract

Cited by 18 publications

References 31 publications

Effect of nano-encapsulated food flavorings on streptozotocin-induced diabetic rats

Effect of nano-encapsulated food flavorings on streptozotocin-induced diabetic rats

Optimization of the conditions for producing water-in-oil-in-water microemulsions and spray-dried microcapsule of tomato extract powder

Essential Oil and Hydrophilic Antibiotic Co-Encapsulation in Multiple Lipid Nanoparticles: Proof of Concept and In Vitro Activity against Pseudomonas aeruginosa

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