Optimized Conformal Paraaortic Lymph Node Irradiation is not Associated with Enhanced Renal Toxicity

Nevinny-Stickel, Meinhard; Poljanc, Karin; Forthuber, Britta; Heute, Dirk; Posch, Andrea; Lechner, Judith; Beer, Beate; Lukáš, Peter; Seppi, Thomas

doi:10.1007/s00066-007-1657-6

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…In the patients analyzed here, relapses tended to occur outside the irradiation field. This supports the findings of other authors who were able to demonstrate that the relapse risk is higher in nonirradiated regions than in areas subjected to adjuvant radiotherapy [1,16,21,28,31,33]. Studies comparing different radiation volumes are scarce in the literature.…”

Section: Time (Years)supporting

confidence: 74%

Long-Term Outcome and Prognostic Factors in Early-Stage Nodal Low-Grade Non-Hodgkin’s Lymphomas Treated with Radiation Therapy

et al. 2009

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Section: Time (Years)supporting

confidence: 74%

Long-Term Outcome and Prognostic Factors in Early-Stage Nodal Low-Grade Non-Hodgkin’s Lymphomas Treated with Radiation Therapy

et al. 2009

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“…However, vaginal cancer affects a more elderly population than cervical cancer, and possible side effects should be carefully considered before combined therapy is recommended [9,10,23,26].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Results of Radiotherapy in Primary Carcinoma of the Vagina

et al. 2009

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Background:The long-term results of radiotherapy in primary carcinoma of the vagina are not well defined. Patients and Methods: The treatment results of 41 patients with primary malignancies of the vagina were analyzed. The mean follow-up period was 77.3 months (2.3-404 months). The predominant histology was squamous cell carcinoma, FIGO stages I: n = 7 (17.1%), II: n = 13 (31.7%), III: n = 13 (31.7%), and IVa: n = 8 (19.5%). Radiotherapy was the primary treatment for all patients. None of the patients had undergone prior surgery for vaginal carcinoma. The majority of patients received pelvic irradiation, including treatment of the inguinal lymphatics (median dose: 50 Gy). 26 patients received additional intravaginal brachytherapy. Results: Overall, 21 patients (51.2%) achieved complete remission, 17 patients (41.5%) had partial responses, and three patients (7.3%) had no change or progressive disease. The total median survival of the analyzed patients was 41.3 months. The 1-year survival probability was 85.4%, the 5-year survival probability 40.6%, and the 10-year survival probability 27.2%. Univariate analysis revealed a survival advantage for earlier tumor stages (FIGO I and II) compared to advanced stages (FIGO III and IV), with a median survival of 58.1 months compared to 26.8 months. Treatment side effects were tolerable and easily managed. Conclusion: Definite radiotherapy is the treatment of choice for primary carcinomas of the vagina. Considering that primary malignancies of the vagina are typically diseases of the elderly, it should be noted that radiotherapy is especially well tolerated in this population. Langzeitergebnisse der Strahlentherapie beim primären VaginalkarzinomHintergrund: Die Langzeitergebnisse der Strahlentherapie beim primären Vaginalkarzinom sind nicht gut definiert. Patienten und Methodik: Die Behandlungsergebnisse von 41 Patientinnen mit primären Vaginalkarzinomen wurden analysiert. Der mittlere Nachbeobachtungszeitraum betrug 77,3 Monate (2,3-404 Monate). Histologisch lagen überwiegend Plattenepithelkarzinome vor, FIGO-Stadien I: n = 7 (17,1%), II: n = 13 (31,7%), III: n = 13 (31,7%), IVa: n = 8 (19,5%). Bei allen Patientinnen war die Strahlentherapie die primäre Behandlungsform, keine Patientin hatte sich vor Bestrahlungsbeginn einer chirurgischen Intervention unterzogen. Der Großteil der Patientinnen erhielt eine Beckenbestrahlung, welche die inguinalen Lymphbahnen einschloss (mittlere Dosis: 50 Gy). 26 Patientinnen erhielten zusätzlich eine intravaginale Brachytherapie. Ergebnisse: Insgesamt erreichten 21 Patientinnen (51,2%) eine komplette Remission, 17 Patientinnen (41,5%) wiesen eine partielle Remission auf, und drei Patientinnen (7,3%) zeigten keine Veränderung bzw. ein Fortschreiten der Erkrankung. Das Gesamtüberleben für alle Patientinnen lag im Median bei 41,3 Monaten. Die 1-Jahres-Überlebenswahrscheinlichkeit betrug 85,4%, die 5-Jahres-Überlebenswahrscheinlichkeit 40,6% und die 10-Jahres-Überlebenswahrscheinlichkeit 27,2%. Die univariate Analyse zeigte einen Überlebensvo...

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“…Kidneys are probably the most radiosensitive abdominal organs; a tolerance dose of 20 Gy has been proposed [18,19,23]. Radiation nephropathy includes increased vascular permeability, perfusion disturbance, inflammatory reactions, and fibrosis [3,7].…”

Section: Introductionmentioning

confidence: 99%

Amifostine Use in Radiation-Induced Kidney Damage

et al. 2008

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Optimized Conformal Paraaortic Lymph Node Irradiation is not Associated with Enhanced Renal Toxicity

Abstract: Conformal irradiation of retroperitoneal lymph nodes with individual PTV delineation appears not to be associated with clinically relevant functional impairment of the kidneys.

Cited by 14 publications

References 30 publications

Long-Term Outcome and Prognostic Factors in Early-Stage Nodal Low-Grade Non-Hodgkin’s Lymphomas Treated with Radiation Therapy

Long-Term Outcome and Prognostic Factors in Early-Stage Nodal Low-Grade Non-Hodgkin’s Lymphomas Treated with Radiation Therapy

Long-Term Results of Radiotherapy in Primary Carcinoma of the Vagina

Amifostine Use in Radiation-Induced Kidney Damage

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