Optimized Dirac Woods-Saxon basis for covariant density functional theory

Zhang, K. Y.; Pan, Chun‐Shui; Zhang, S. Q.

doi:10.1103/physrevc.106.024302

Cited by 21 publications

(4 citation statements)

References 78 publications

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“…Based on the DRHBc theory, the angular momentum projection has been implemented to investigate the low-lying spectra of neutronrich magnesium isotopes [19,20], and the finite amplitude method has been developed to study the isoscalar giant monopole resonance in exotic nuclei [21]. The optimization of the DRHBc theory has been studied for the multipole expansion of nuclear densities [22], the Dirac Woods-Saxon (DWS) basis optimized [23], and the dynamical correlation energy and the nuclear shape evolution explored by the two-dimensional collective Hamiltonian (2DCH) [24,25].…”

mentioning

confidence: 99%

Nuclear mass table in deformed relativistic Hartree–Bogoliubov theory in continuum, I: Even–even nuclei

Zhang

Cheoun

Choi

et al. 2022

Atomic Data and Nuclear Data Tables

109

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mentioning

confidence: 99%

Nuclear mass table in deformed relativistic Hartree–Bogoliubov theory in continuum, I: Even–even nuclei

Zhang

Cheoun

Choi

et al. 2022

Atomic Data and Nuclear Data Tables

109

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“…The second step is to identify control hubs 31 . To focus on Covid-19, we left the technical details of our new method for finding control hubs to Methods and Supplemental Method S3.…”

Section: Resultsmentioning

confidence: 99%

“…1B ). All control hubs can be identified in polynomial time without computing all control schemes 31 ; the algorithmic details are available in our previous work 31 .…”

Section: Methodsmentioning

confidence: 99%

Total network controllability analysis discovers explainable drugs for Covid-19 treatment

Wei

Pan

Zhang

et al. 2023

Preprint

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Background The active pursuit of network medicine for drug repurposing, particularly for combating Covid-19, has stimulated interest in the concept of structural control capability in cellular networks. We sought to extend this theory, focusing on the defense rather than control of the cell against viral infections. Accordingly, we extended structural controllability to total structural controllability and introduced the concept of control hubs. Perturbing any control hub may render the cell uncontrollable by exogenous stimuli like viral infections, so control hubs are ideal drug targets. Results We developed an efficient algorithm to identify all control hubs, applying it to the largest homogeneous network of human protein interactions, including interactions between human and SARS-CoV-2 proteins. Our method recognized 65 druggable control hubs with enriched antiviral functions. Utilizing these hubs, we categorized potential drugs into four groups: antiviral and anti-inflammatory agents, drugs acting on the central nervous system, dietary supplements, and compounds enhancing immunity. An exemplification of our approach's effectiveness, Fostamatinib, a drug initially developed for chronic immune thrombocytopenia, is now in clinical trials for treating Covid-19. Preclinical trial data demonstrated that Fostamatinib could reduce mortality rates, ICU stay length, and disease severity in Covid-19 patients. Conclusions Our findings confirm the efficacy of our novel strategy that leverages control hubs as drug targets. This approach provides insights into the molecular mechanisms of potential therapeutics for Covid-19, making it a valuable tool for interpretable drug discovery.

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“…Both SWS and DWS bases have been widely applied to various nuclear models to study weakly bound nuclei [58][59][60]71,72]. Recently, an optimized DWS basis whose corresponding potential is close to the nuclear mean field is proposed, and its basis space required for convergence is substantially reduced compared to the original one [73].…”

Section: Solving the Rhb Equationmentioning

confidence: 99%

Spherical, Axial, and Triaxial Symmetries in the Study of Halo Nuclei with Covariant Density Functional Theory

et al. 2023

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The halo phenomenon in exotic nuclei has long been an important frontier in nuclear physics research since its discovery in 1985. In parallel with the experimental progress in exploring halo nuclei, the covariant density functional theory has become one of the most successful tools for the microscopic study of halo nuclei. Based on spherical symmetry, the relativistic continuum Hartree–Bogoliubov theory describes the first halo nucleus 11Li self-consistently and predicts the giant halo phenomenon. Based on axial symmetry, the deformed relativistic Hartree–Bogoliubov theory in continuum has predicted axially deformed halo nuclei 42,44Mg and the shape decoupling effects therein. Based on triaxial symmetry, recently the triaxial relativistic Hartree–Bogoliubov theory in continuum has been developed and applied to explore halos in triaxially deformed nuclei. The theoretical frameworks of these models are presented, with the efficacy of exploiting symmetries highlighted. Selected applications to spherical, axially deformed, and triaxially deformed halo nuclei are introduced.

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Optimized Dirac Woods-Saxon basis for covariant density functional theory

Cited by 21 publications

References 78 publications

Nuclear mass table in deformed relativistic Hartree–Bogoliubov theory in continuum, I: Even–even nuclei

Nuclear mass table in deformed relativistic Hartree–Bogoliubov theory in continuum, I: Even–even nuclei

Total network controllability analysis discovers explainable drugs for Covid-19 treatment

Spherical, Axial, and Triaxial Symmetries in the Study of Halo Nuclei with Covariant Density Functional Theory

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