Optimized extraction of sulfated polysaccharide from brown seaweed Sargassum polycystum and its evaluation for anti-cancer and wound healing potential

Digala, Prathapavarma; Saravanan, Muthupandian; Dhanraj, Manoj; Pamarthi, Jayakrishna; Suganthi, Muralidharan; Narikimelli, Akhila; Dinakaran, K.P.; Arokiyaraj, Selvaraj; Vincent, Savaraiar

doi:10.1016/j.sajb.2022.03.015

Cited by 12 publications

(1 citation statement)

References 33 publications

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“…Brown algae contain phenolic compounds, including flavonoids, phlorotannins, fucoxanthin, cinnamic acid, and benzoic acid (4,6). Several studies have been declared on various biological activities of brown algae species like anticancer, antibacterial, antidepressant, antidiabetic, and wound healing (7)(8)(9)(10)(11). Previous studies have also reported the inflammatory inhibition of hexane, chloroform, and ethanol extracts of Sargassum swartzii (6,12).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Sargassum polycystum ethyl acetate extract from Indonesia

Sianipar,

Gunardi

2023

J Herbmed Pharmacol

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Introduction: Inflammatory diseases, including asthma, osteoarthritis, rheumatoid arthritis, and cancer persist with relatively high incidence, which highlights the need to explore natural alternatives such as the bioactive substances of brown algae (Sargassum polycystum). Certain substances, such as phenolics and flavonoids, have been demonstrated to have an association with antioxidant activity because of their capacity to fend off free radicals, which cause inflammation. The purpose of this study was to look into the inflammatory inhibition and antioxidant activity of an ethyl acetate extract of S. polycystum from Indonesia. Methods: After maceration in ethyl acetate (1:4 w/v) for 24 hours, the total phenolic and flavonoid content of S. polycystum extract was measured using the colorimetric method. The antioxidant activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), and the models of paw edema induced by carrageenan were used to assess inflammatory inhibition activity. Results: The findings revealed that S. polycystum had a weak antioxidant with a half-maximal inhibitory concentration (IC50) value of 605.24 ± 26.53 g/mL. Furthermore, it had 23.509 ± 0.109 mg gallic acid equivalents/gram (GAE/g) and 15.186 ± 0.046 mg quercetin equivalents/ gram (QE/g) of total phenolic and flavonoid compounds, respectively. At 200, 400, and 800 mg/ kg BW doses, S. polycystum had inflammatory inhibition percentages of 53.80 ± 4.68%, 62.35 ± 4.05%, and 60.90 ± 2.88%, respectively. Conclusion: Sargassum polycystum ethyl acetate extract inhibited inflammation. However, further study is needed to examine the safety, identification, separation of the relevant substances involved, and the precise mechanism of action.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Sargassum polycystum ethyl acetate extract from Indonesia

Sianipar,

Gunardi

2023

J Herbmed Pharmacol

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Alginate's ability to prevent metabolic illnesses, the degradation of the gut's protective layer, and alginate‐based encapsulation methods

Ahmad,

Riaz,

Desta

2024

Food Science & Nutrition

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The gut serves as the body's main immunological and digestive system. Furthermore, host immunity is mostly managed there. Nutrients are further broken down and absorbed here. Numerous research investigations have shown evidence that inflammation, oxidative stress, impairment of the intestinal barrier, and imbalance in the gut microbiota can all contribute to a variety of intestinal illnesses and other issues, underscoring the growing significance of intestinal health concerns. Because of their high biological activity and lack of negative side effects, the organic food‐derived chemicals known as brown algal polysaccharides—mainly fucoidan, laminaran, and alginate—have attracted a lot of attention from academics. Because of its many benefits, sodium alginate is one of the biopolymers that has garnered the greatest attention, research, and application. Carotenoids, which are found in our food, have several positive health effects. Their low solubility in water, oxidation susceptibility, chemical instability, accessibility, and restricted solubility in water, however, restrict their use in food and medicine. In this review and in overcoming these constraints, encapsulation might be helpful. Furthermore, the primary goal of our study is to provide a fresh perspective into the control and avoidance of intestinal diseases. It provides more potent alternatives to this system, clarifies the function of alginates in enhancing the encapsulation of carotenoids, and functions as a model for the synthesis of the intestinal protective agent fucoidan.

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Extraction, Purification, Structural Characteristics, and Biological Activities of Seaweed Polysaccharides: A Review

Yang,

Deng,

Chen

et al. 2024

Starch Stärke

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This paper presents a thorough review of the extraction, purification, structural characterization, and biological activities of polysaccharides obtained from seaweed. The focus is on the polysaccharide compositions of green algae, brown algae, and red algae, which are systematically compared and analyzed. It has been discovered that while there are similarities in the extraction and purification processes of seaweed polysaccharides, there are also significant differences and unique features in their structural characteristics and biological activities. These differences are not only reflected in the chemical composition of the polysaccharides but are also closely related to their sources and extraction methods. The relationship between the structure and activity of seaweed polysaccharides will aid in comprehending the biological activity mechanism of marine organisms. This review provides a theoretical basis and practical guidance for the development of new types of marine drugs or functional foods.

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Optimized extraction of sulfated polysaccharide from brown seaweed Sargassum polycystum and its evaluation for anti-cancer and wound healing potential

Cited by 12 publications

References 33 publications

Anti-inflammatory and antioxidant properties of Sargassum polycystum ethyl acetate extract from Indonesia

Anti-inflammatory and antioxidant properties of Sargassum polycystum ethyl acetate extract from Indonesia

Alginate's ability to prevent metabolic illnesses, the degradation of the gut's protective layer, and alginate‐based encapsulation methods

Extraction, Purification, Structural Characteristics, and Biological Activities of Seaweed Polysaccharides: A Review

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