Optimized ion selective electrode for determination of Tamsulosin hydrochloride in the presence of co-formulated Deflazacort in bulk, tablet dosage form and human urine

Green Electrochemical Sensing: Novel Ion-Selective Electrode Method for Precise Determination of Dimenhydrinate and its Metabolite along with Cinnarizine in Pharmaceutical and Plasma Samples

“…The detection limit for CIN, DMH and DIP was highly sensitive using MWCNTs/SPE which was equal to 0.5 × 10 −6 , 1.0 × 10 −7 , 0.2 × 10 −6 . The selection of the appropriate ionophores namely calix [8]arene, resorcinarene and β-CD and cation exchanger namely K.tetrakis and Na.TPB played a crucial role in optimizing the microfabrication process of the drug of interest CIN and DMH as well as DIP "active metabolite of DMH" with acceptable precision and accuracy. The optimized multi wall carbon nano tube screen-printed electrode demonstrated compliance with the guidelines set by the International Union of Pure and Applied Chemistry (IUPAC).…”

“…Sodium tetraphenylborate (NaTPB) and potassium tetrakis (4-chlorophenyl) borate as ion-exchangers were purchased from (Sigma Aldrich, Germany). Calix [4] arene (CX4), Calix [6] arene (CX6), Calix [8] arene (CX8), 2-Hydroxy propyl β-cyclo dextrin (β-CD) and C-Undecylcalix [4]resorcinarene monohydrate (CX4Res) as ionophores were purchased from (Sigma Aldrich, Munich, Germany). 2-nitrophenyl octyl ether (o-NPOE) (Sigma Aldrich, Munich, Germany) as plasticizer.…”

“…The various impressive properties of CNTs in being highly hydrophobic, inert and couldn't be affected by light, oxygen or carbon dioxide make their applicability in SC-ISE a first choice. 8,9 Enhanced selectivity as well as sensitivity was observed in electrode activity when incorporating ionophores aside with transducers. The use of ionophores can result in improved sensitivity through enhancing the transfer of the target ion across the polymeric membranes.…”

Separation of tamsulosin enantiomers by capillary electrophoresis with tandem mass spectrometry and online stacking preconcentration

“…Tamsulosin was analysed under achiral conditions by e.g. , HPLC-UV, 18–20 HPLC-MS, 21–23 electrochemical methods, 24,25 or fluorescence. 26,27 Separation of tamsulosin enantiomers was performed by HPLC 28–30 and CE.…”

“…It is metabolized, mainly by cytochrome P450, to compounds with low abundance, and 8-15% of an oral dose is excreted renally as the parent compound. 17 Tamsulosin was analysed under achiral conditions by e.g., HPLC-UV, [18][19][20] HPLC-MS, [21][22][23] electrochemical methods, 24,25 or uorescence. 26,27 Separation of tamsulosin enantiomers was performed by HPLC [28][29][30] and CE.…”