Optimized metal-organic-framework based magnetic nanocomposites for efficient drug delivery and controlled release

Current status of controlled onco-therapies based on metal organic frameworks

“…For example, by conjugating Fe 3 O 4 MNPs with MIL-88B-NH 2 MOF structures using optimized synthetic media (which contains acetic acid as a modulating agent and F127 co-polymer as a stabilizing agent), Attia et al successfully produced a well-controlled hybrid magnetic nanocomposite; by loading carmustine and mertansine, two drugs against glioblastoma, into the pores of this MOF nanocomposite, they achieved significant cancer cell toxicity yet limited side effects. 55…”

Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

“…Moreover, localized heating was caused as a result of the magnetic local minimum included in the MOF NPs when a modified magnetic field was practiced on the magnetic nanocomposites loaded with DM1 to accomplish controlled drug release. To verify the therapeutic effectiveness of the DDS on U251 glioblastoma cells, in vitro cytotoxicity experiments were performed ( Figure 10 ) [ 137 ].…”

“… ( a ) F127 copolymer was used as a stabilizing substance during the synthesis of MOF Fe 3 O 4 NPs with MIL-88B-NH2 structures, and these nanoparticles were used to deliver drugs using an alternating magnetic field and localized heating effect; ( b ) a preassembled Fe 2 Mn(3-O) cluster was used to create an FeMn-based ferromagnetic MOF that controlled drug release by dual stimulation, ferromagnetic nature, and low toxicity. Reproduced with permission from references [ 137 , 138 ]. …”

Progress and opportunities for metal–organic framework composites in electrochemical sensors

“…[1][2][3][4] Owing to the diversity of organic ligands and metal ions, various MOFs have been developed and attracted the attention of researchers in chemistry, materials science, and physics. 5,6 Compared with conventional porous materials, MOFs with increased specic surface area, improved porosity, and enhanced catalytic efficiency, have been widely applied in gas adsorption and storage, [7][8][9] catalysis, [10][11][12][13] batteries, [14][15][16][17] drug release, [18][19][20][21] and supercapacitors. [22][23][24][25] However, the electrochemical applicability of a single MOF is limited by shortcomings such as poor water stability, low conductivity, and low mechanical strength.…”