Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study

Poomanee, Worrapan; Yaowiwat, Nara; Pattarachaidaecharuch, Tunpidcha; Leelapornpisid, Pimporn

doi:10.1038/s41598-023-32738-7

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…(All data are shown as mean ± SD of at least three independent experiments. * P < 0.05; ** P < 0.01) vironmental stimulation [38]. One obvious physical sign of skin senescence is the degradation of the ECM.…”

Section: Resultsmentioning

confidence: 98%

Vanilla pompona Leaves and Stems as New Sources of Bioactive Compounds: The Therapeutic Potential for Skin Senescence

et al. 2023

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A large variety of natural plants are widely produced and utilised because of their remarkable pharmacological effects. In this study, two phenolic glycosides were isolated for the first time from Vanilla pompona Schiede (Orchidaceae) from Kyushu, Japan: bis [4-(β-D – O-glucopyranosyloxy)-benzyl] (S)-2-isopropylmalate (1) and bis 4-[β-D-O-glucopyranosyloxy)-benzyl]-(2R,3S)-2-isopropyl tartrate (2). We have discovered that the crude extract of V. pompona leaves and stems and its two phenolic glycosides (compounds 1 – 2) are highly effective in reversing skin senescence. V. pompona and compounds 1 – 2 were found to promote the synthesis of collagen, hyaluronic acid, and elastin in skin fibroblasts in a normal skin cell model; in a replicative senescence model, V. pompona and compounds 1 – 2 significantly reduced the ageing phenotype in skin fibroblasts. These compounds also demonstrated a significant protective effect in a UV-induced photo-senescence model; the possible mechanisms of this effect were investigated in this study. To the best of our knowledge, this study is the first to develop V. pompona leaves and stems as new sources of bioactive compounds and to examine their therapeutic potential for skin senescence. The development potential of V. pompona leaves and stems for use in the cosmetics, cosmeceutical, and pharmaceutical industries remains to be investigated.

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Section: Resultsmentioning

confidence: 98%

Vanilla pompona Leaves and Stems as New Sources of Bioactive Compounds: The Therapeutic Potential for Skin Senescence

et al. 2023

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“…Se atribuye este efecto a las propiedades antioxidantes de EM de disminuir los ROS, por lo tanto, impedir la formación de metaloproteinasas, en consecuencia, menor daño al colágeno y elastina; también tiene propiedades antirosinasa, involucrada en la aparición de manchas (lentigos solares) debido a su acción en la melanogénesis, por otro lado, CA promueve el inicio de la producción de colágeno especialmente el tipo I pues activa la vía SMAD/factor de crecimiento beta. (16) En la extracción de componentes polifenólicos, de la semilla del mango y su efecto como posible alternativa al tratamiento, eliminan ROS, reduce la actividad de la tirosinasa; anti-metaloproteinasas; inhibe el óxido nítrico, IL 6 e IL 8. Sin embargo, estos resultados solo son in vitro y no se puede aun saber la efectividad como tratamiento en la piel humana.…”

Section: Tratamientounclassified

Molecular approach to skin aging: new perspectives

Fiallos,

Batista Castro

2024

Salud, Ciencia y Tecnología

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Introducción: el envejecimiento cutáneo es un proceso fisiológico que causa preocupación en las personas, al modificar las características morfológicas de la piel; más allá de lo estético la piel es un órgano con diversas funciones, como protección, secreción de hormonas, regulación de la temperatura; el envejecimiento puede ser de dos tipos: intrínseco, producido por la senescencia de las células, el extrínseco: producido por la interacción de todos los componentes de la piel y factores externos, el más conocido es los rayos ultravioletas (UV)provenientes del sol.

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“…In some studies, plants have been shown to exert notable in vivo anti-aging properties. According to the literature, skin parameters associated with skin aging, such as skin hydration (measured with a corneometer and tewameter), skin elasticity (measured with a cutometer and elastometer) or facial wrinkles (measured with a skin visiometer and camera for skin analysis) have been evaluated following the application of cosmetic formulations based on various plant extracts, alone or in combination [119,[150][151][152]. Table 3 cites research from the last five years on selected plant species and their extracts with potential uses as agents preventing and slowing down skin aging.…”

Section: Plants As Anti-aging Agentsmentioning

confidence: 99%

Plant Extracts as Skin Care and Therapeutic Agents

Michalak

2023

IJMS

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Natural ingredients have been used for centuries for skin treatment and care. Interest in the health effects of plants has recently increased due to their safety and applicability in the formulation of pharmaceuticals and cosmetics. Long-known plant materials as well as newly discovered ones are increasingly being used in natural products of plant origin. This review highlights the beneficial effects of plants and plant constituents on the skin, including moisturizing (e.g., Cannabis sativa, Hydrangea serrata, Pradosia mutisii and Carthamus tinctorius), anti-aging (e.g., Aegopodium podagraria, Euphorbia characias, Premna odorata and Warburgia salutaris), antimicrobial (e.g., Betula pendula and Epilobium angustifolium), antioxidant (e.g., Kadsura coccinea, Rosmarinus officinalis, Rubus idaeus and Spatholobus suberectus), anti-inflammatory (e.g., Antidesma thwaitesianum, Helianthus annuus, Oenanthe javanica, Penthorum chinense, Ranunculus bulumei and Zanthoxylum bungeanum), regenerative (e.g., Aloe vera, Angelica polymorpha, Digitaria ciliaris, Glycyrrihza glabra and Marantodes pumilum), wound healing (e.g., Agrimonia eupatoria, Astragalus floccosus, Bursera morelensis, Jatropha neopauciflora and Sapindus mukorossi), photoprotective (e.g., Astragalus gombiformis, Calea fruticose, Euphorbia characias and Posoqueria latifolia) and anti-tyrosinase activity (e.g., Aerva lanata, Bruguiera gymnorhiza, Dodonaea viscosa, Lonicera japonica and Schisandra chinensis), as well as their role as excipients in cosmetics (coloring (e.g., Beta vulgaris, Centaurea cyanus, Hibiscus sabdariffa and Rubia tinctiorum), protective and aromatic agents (e.g., Hyssopus officinalis, Melaleuca alternifolia, Pelargonium graveolens and Verbena officinalis)).

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Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study

Cited by 7 publications

References 21 publications

Vanilla pompona Leaves and Stems as New Sources of Bioactive Compounds: The Therapeutic Potential for Skin Senescence

Vanilla pompona Leaves and Stems as New Sources of Bioactive Compounds: The Therapeutic Potential for Skin Senescence

Molecular approach to skin aging: new perspectives

Plant Extracts as Skin Care and Therapeutic Agents

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