Optimized preparation of gastric acid-response sulfhydryl functionalized chitosan/alginate/tilapia peptide hydrogel and its protective effects on alcohol-induced liver and brain injury

Lu, Sitong; Zhang, Lingyu; Zhang, Hu; Kong, Songzhi; Zhang, Zhaoyu; Li, Guangfa

doi:10.1039/d1ra06361h

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…Medicina 2022, 58, x FOR PEER REVIEW 10 of 19 35.43) compared to the control group (1193.85 ± 29.37) was registered after 14 days of the experiment (Figure 5c). No momentous changes in LDH activity were observed in the CHIT, CHIT-ves or AcA group by comparison withthe control group after 14 days of the experiment (Figure 5c).…”

Section: Hematological Testsmentioning

confidence: 91%

“…Alcohol exerts toxic effects on the hepatocellular level, represented by the increased serum level of transaminases following their release into the circulation, after cell destruction. At the same time, there is an intensification of oxidative stress and lipid peroxidation as a result of the alteration of proteins and lipids by free radicals resulting from hepatocyte damage.Treatment with chitosan and chitosan vesicles resulted in a significant decrease in liver enzyme activity, which may be attributed to the antioxidant and anti-inflammatory effects of this polysaccharide [30,34,35]. The repair actions of chitosan and chitosan vesicles can be explained by a possible stabilizing effect of the hepatocyte membrane, preventing the release of transaminases into the blood.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

et al. 2022

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Background and Objectives In the past few decades, the studies concerning the natural polysaccharide chitosan have been centered on a new direction: its hepatoprotective action. The aim of our study was to evaluate the influence of previously designed chitosan lipid vesicles on the liver damage induced by alcohol consumption in mice. Materials and Methods The study involved the oral administration of substances in one daily dose as follows: Group 1 (control): water; Group 2 (control alcohol): 5% alcohol in water; Group 3 (CHIT): 0.1 mL/10 g body weight chitosan solution in animals treated with alcohol; Group 4 (CHIT-ves): 0.1 mL/10 g body chitosan vesicles in animals treated with alcohol; Group 5 (AcA): 200 mg/kg body ascorbic acid in animals treated with alcohol. In order to evaluate liver damage after alcohol consumption, the following hematological parameters were tested: the activity of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase; serum values of urea and creatinine; the phagocytic capacity of polymorphonuclear neutrophilsin peripheral blood;serum opsonic capacity;bactericidal capacity of peritoneal macrophages; and the activity of malondialdehyde, glutathione peroxidase, superoxide dismutase and lactate dehydrogenase. Results and Conclusion The treatment with chitosan vesicles decreased liver enzyme activity and reduced the oxidative stress disturbances in alcoholic mice, thus repairing the hepatic functional and structural damages. These beneficial activities of chitosan vesicles were comparable with ascorbic acid effects in alcoholic mice.

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Section: Hematological Testsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

et al. 2022

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“…In addition, the HNF-4α and transferrin are upregulated, indicating the restored function of the liver [ 210 ]. Furthermore, chitosan-N-acetyl-l-cysteine/sodium alginate/tilapia peptide reduces liver injuries in mice caused by alcoholism [ 211 ].…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Chitosan nanoparticles-hydrogel composites for biomedical applications

Banazadeh,

Ilaghi,

Abadi

et al. 2025

Fundamentals and Biomedical Applications of Chitosan Nanoparticles

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Optimized preparation of gastric acid-response sulfhydryl functionalized chitosan/alginate/tilapia peptide hydrogel and its protective effects on alcohol-induced liver and brain injury

Abstract: Long-term alcohol intake or drinking large quantities of alcohol at one time can cause organ damage, which in turn can lead to chronic diseases.

Cited by 5 publications

References 40 publications

The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Chitosan nanoparticles-hydrogel composites for biomedical applications

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