Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Di, Yifan; Deng, Ruizhu; Liu, Zhu; Mao, Yuling; Gao, Yikun; Zhao, Qinfu; Wang, Siling

doi:10.1016/j.biomaterials.2023.122391

Cited by 26 publications

(2 citation statements)

References 429 publications

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“…In addition to the internal stimuli-responsive nanomedicines, external stimuli-responsive nanoparticles have been widely developed for nanotheranostics over the last decades. − In the early phase of development, sensitizers that could be activated with an external energy source, including light, US, and radio, were demonstrated; PDT, PTT, SDT, and radiodynamic therapy (RDT) were estimated using these sensitizers. Recently, growing interest in immunotherapy has led to a focus on ICD through DAMPs and pathogen-associated molecular patterns (PAMPs), which are byproducts of PDT, PTT, SDT, and RDT.…”

Section: Stimuli-responsive Polymeric Nanomedicine For Cancer Immunot...mentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim,

Lee,

et al. 2024

Chem. Mater.

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Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as a promising approach for counteracting the evasive tactics of cancer cells. This study delves into the innovative realm of stimuli-responsive polymeric nanomedicines in the context of cancer immunotherapy. By capitalizing on the intricate landscape of the tumor microenvironment (TME), which orchestrates immune suppression and tumor progression, stimuli-responsive nanomedicines offer a tailored strategy to enhance therapeutic interventions. The aberrant features of the TME, which include factors such as low pH, inflammation, oxidative stress, and enzyme overexpression, serve as triggers for intelligent delivery systems facilitated by functional polymers. This dynamic approach has the potential to overcome the challenges faced by traditional nanoparticle-based immunotherapy techniques, presenting a platform to precisely optimize drug delivery within the tumor locale. As the synergistic interaction between stimuli-responsive polymeric nanomedicines and the TME unfolds, a novel horizon emerges to advance the efficacy of cancer immunotherapy while mitigating its associated limitations.

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Section: Stimuli-responsive Polymeric Nanomedicine For Cancer Immunot...mentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim,

Lee,

et al. 2024

Chem. Mater.

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“…In particular, due to reactive oxygen species (ROS) with mitigated side effects, − one of the major applications is TME-responsive catalytic therapy of SAzymes without off-target toxicity to surrounding normal tissues. Nevertheless, the intricate tumor microenvironment (TME) greatly limits the therapeutic effects of SAzymes.…”

Section: Introductionmentioning

confidence: 99%

Rearranging Spin Electrons by Axial-Ligand-Induced Orbital Splitting to Regulate Enzymatic Activity of Single-Atom Nanozyme with Destructive d−π Conjugation

Zhao,

Zhang,

Gao

et al. 2024

J. Am. Chem. Soc.

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Most of the nanozymes have been obtained based on trial and error, for which the application is usually compromised by enzymatic activity regulation due to a vague catalytic mechanism. Herein, a hollow axial Mo−Pt single-atom nanozyme (H-MoN 5 @PtN 4 /C) is constructed by a two-tier template capture strategy. The axial ligand can induce Mo 4d orbital splitting, leading to a rearrangement of spin electrons (↑ ↑ → ↑↓) to regulate enzymatic activity. This creates catalase-like activity and enhances oxidase-like activity to catalyze cascade enzymatic reactions (H 2 O 2 → O 2 → O 2 •− ), which can overcome tumor hypoxia and accumulate cytotoxic superoxide radicals (O 2 •− ). Significantly, H-MoN 5 @PtN 4 /C displays destructive d−π conjugation between the metal and substrate to attenuate the restriction of orbitals and electrons. This markedly improves enzymatic performance (catalaselike and oxidase-like activity) of a Mo single atom and peroxidase-like properties of a Pt single atom. Furthermore, the H-MoN 5 @ PtN 4 /C can deplete overexpressed glutathione (GSH) through a redox reaction, which can avoid consumption of ROS (O 2 •− and • OH). As a result, H-MoN 5 @PtN 4 /C can overcome limitations of a complex tumor microenvironment (TME) for tumor-specific therapy based on TME-activated catalytic activity.

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