The spatiotemporal evolution of seismic activity is presented for a broad region surrounding the focal areas of the 2021 M 7.3 and 2022 M 7.4 Fukushima-Oki earthquakes, which occurred within the subducting slab off the Pacific coast of Fukushima Prefecture, northeastern Japan. This study investigates the spatiotemporal variations in seismic activity during the periods before the 2021 M 7.3 earthquake, between the 2021 M 7.3 and 2022 M 7.4 earthquakes, and after the 2022 M 7.4 earthquake using the b -value of the Gutenberg–Richter relation, the aftershock decay rate ( p -value), and changes in the seismicity rate (Z -value). The study area is also divided into two depth sections to investigate the depth variations in these seismicity parameters relative to the plate interface. The b -values in the deeper section (intraslab) are generally lower than those in the shallower section (around the plate interface) throughout the entire analysis period, including the hypocentral areas of the M 7.3 and M 7.4 earthquakes. The aftershock decay rates for the M 7.3 and M 7.4 earthquakes also show depth-dependent characteristics, with a slower decay rate ( p < 1.0) at many grid nodes in the deeper section than in the shallower section. Furthermore, seismic quiescence was noted in the hypocentral area of the M 7.3 earthquake about two years before the occurrence of this mainshock. The locations of the M 7.3 and M 7.4 earthquakes around the down-dip edge of the slip area of the 2011 M 9.0 Tohoku earthquake suggests that the variations in seismic activity detected in this study mainly reflect stress increases due to the coseismic slip and postseismic deformation of this great earthquake. The present study suggests that the effect of viscoelastic relaxation is a dominant factor in the deeper section. Furthermore, the variations in seismicity may also reflect heterogeneous structures within the slab.