Optimizing and modeling of effective parameters on the structural and magnetic properties of Fe3O4 nanoparticles synthesized by coprecipitation technique using response surface methodology

Ghazanfari, Mohammad Reza; Kashefi, Mehrdad; Jaafari, Mahmoud Reza

doi:10.1016/j.jmmm.2016.02.094

Cited by 20 publications

(5 citation statements)

References 41 publications

(53 reference statements)

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“… 1 - 5 In magnetic hyperthermia, the magnetic nanoparticles (MNPs) are exposed to a magnetic field to provide the required energy for temperature rise. 6 - 10 The temperature (around 42-44℃) damages the tumor cells without any significant injury to the tissues. Depending on the crystalline degree and the size of the nanoparticles, the therapeutic performance be change.…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the crystalline degree and the size of the nanoparticles, the therapeutic performance be change. 10 , 11 Till now, many kinds of magnetic structures have been introduced for hyperthermia purposes including magnetite, spinel ferrites, and manganese-based perovskite structures. 12 - 15 The Fe 3 O 4 nanoparticles have been the best option for biomedical applications because of high thermal resistance, chemical stability, and high saturation magnetization.…”

Section: Introductionmentioning

confidence: 99%

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Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

2022

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Purpose: Magnetic hyperthermia is a treatment method based on eddy currents, hysteresis, and relaxation mechanisms of magnetic nanoparticles (MNPs). MNPs such as Fe3O4 have the ability to generate heat under an alternating magnetic field. Heat sensitive liposomes (Lip) convert from lipid layer to liquid layer through heat generated by MNPs and can release drugs. In this research we explore whether combining liposomes, Doxorubicin (DOX) and Magnetic Nanoparticles could help magnetic hypothermia treatment be even more effective in treating cancerous tumors. Methods: In this study, different groups of DOX, MNPs and liposomes were evaluated. The superparamagnetic nano materials were synthesized by co-precipitation method. The MNPs, DOX and a combination of MNPs and DOX were efficiently loaded into the liposomes using the evaporator rotary technique. Magnetic properties, microstructure, specific absorption rate in MNPs, zeta potential, loading percentage of the MNPs and DOX concentration in liposomes, in vitro drug release of liposomes were studied. Finally, the necrosis percentage of cancer cells in C57BL/6J mice bearing melanoma tumors was assessed for all groups. Results: The loading percentages of MNPs and concentration of DOX in the liposomes were 18.52 and 65% respectively. The average size of Lip-DOX-MNPs obtained was 460 nm. The Lip-DOX-MNPs at the buffer citrate solution, showed highly specific absorption rate as the solution temperature reached 42°C in 5 min after exposure to alternative magnetic field. The release of DOX occurred in a pH-dependent manner. The volume of tumor in the therapeutic groups containing the MNPs significantly decreased compared to the others. Numerical analysis showed that the tumor volume in mice receiving Lip-MNPs-DOX was 9.29% that of the control and a histological examination of the tumor section showed 70% necrosis. Conclusion: The Lip-DOX-MNPs could be effective agents which reduce malignant skin tumors growth and increase cancer cell necrosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

2022

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“…During the coprecipitation synthesis, the nucleation and growth of MNPs are affected simultaneously by numerous parameters, such as total Fe concentration, the ratio of Fe(III) and Fe(II) precursors, the nature and concentration of the base, as well as the temperature [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Steering the synthesis of Fe3O4 nanoparticles under sonication by using a fractional factorial design

Echeverría

Moriones

Garrido

et al. 2021

Materials Chemistry and Physics

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“…Numerous optimization designs for experiments have used the RSM method, because central composite design (CCD) has limited effective factors (Bezerra et al 2008). RSM has been successfully used in MNPs and other areas of research (Ghazanfari et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Using experimental design for the screening and optimization of key factors on silica particles adsorption using magnetic nanoparticles – a case study of chemical mechanical polishing wastewater treatment

Huang

Chu

et al. 2017

Water Practice and Technology

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This study applied magnetic nanoparticles (MNPs) to chemical mechanical polishing wastewater treatment using experimental design (Plackett–Burman methods) to select the key factors among pH, mixing, Polyaluminum chloride dosage, settling time, MNPs dosage, and temperature and using response surface methodology (RSM) to determine the optimal values of key factors. Research results showed that the key factors influencing processing performance were pH and rpm, and the optimal conditions were a pH of 4.9 and rpm of 68. The turbidity removal rate through RSM simulation was 90%; under this parameter, the actual turbidity removal rate in the experiment was 89%, which was extremely close to the simulation value; this value was also much higher than the nonoptimized removal rate of 61 ± 8%. Additionally, in the subsequent regeneration and reuse experiment involving mixing and ultrasound for desorption and regeneration, the number of recoveries were 4 and 5, respectively. The study showed that the average particle size of MNPs following ultrasonic vibration was reduced; the effect was optimal at 23 to 15 nm. Therefore, a removal rate of over 80% could be maintained for the fifth ultrasonic regeneration, and the energy of the mixing method may not have been sufficient, causing incomplete desorption and a turbidity removal rate of only 71%.

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Optimizing and modeling of effective parameters on the structural and magnetic properties of Fe3O4 nanoparticles synthesized by coprecipitation technique using response surface methodology

Cited by 20 publications

References 41 publications

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

Steering the synthesis of Fe3O4 nanoparticles under sonication by using a fractional factorial design

Using experimental design for the screening and optimization of key factors on silica particles adsorption using magnetic nanoparticles – a case study of chemical mechanical polishing wastewater treatment

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