Optimizing Chitosan/Collagen Type I/Nanohydroxyapatite Cross-linked Porous Scaffolds for Bone Tissue Engineering

Karakeçili, Ayşe; Korpayev, Serdar; Orhan, Kaan

doi:10.1007/s12010-022-03962-0

Cited by 15 publications

(15 citation statements)

References 37 publications

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“…98 Meanwhile, gelatin is well known for its hydrophilicity, which enables cells to adhere, proliferate, and migrate to the scaffold. 99 In addition, PEDOT:PSS itself has been found to contribute to cell viability, attachment, and proliferation in various previous studies 61,100 due to its hydrophilicity and biocompatibility.…”

Section: Resultsmentioning

confidence: 98%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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Section: Resultsmentioning

confidence: 98%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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“…MC and other related absorbable materials gradually degrade in vivo , while bone tissue grows into the scaffold, the mechanical properties of the scaffold gradually decrease, and the biological stress is transferred from the graft material to the new bone tissue, promoting bone regeneration while avoiding stress shielding [ 104 ]. MC not only has its own good bone repair ability, but also can be combined with polymer materials, metal elements, inorganic materials and so on [ 45 , 105 , 106 ], and can also be equipped with drugs that promote vascular growth and bone regeneration and jointly play an osteogenic role.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair

Zhu

Yao

et al. 2023

Regenerative Biomaterials

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At this stage, bone defects caused by trauma, infection, tumor, or congenital diseases are generally filled with autologous bone or allogeneic bone transplantation, but this treatment method has limited sources, potential disease transmission, and other problems. Ideal bone graft materials remain continuously explored, and bone defect reconstruction remains a significant challenge. Mineralized collagen prepared by bionic mineralization combining organic polymer collagen with inorganic mineral calcium phosphate can effectively imitate the composition and hierarchical structure of natural bone and has good application value in bone repair materials. Magnesium, strontium, zinc, and other inorganic components not only can activate relevant signaling pathways to induce differentiation of osteogenic precursor cells, but also stimulate other core biological processes of bone tissue growth and play an important role in natural bone growth, and bone repair and reconstruction. This study reviewed the advances in hydroxyapatite/collagen composite scaffolds and osseointegration with natural bone inorganic components such as magnesium, strontium, and zinc.

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“…Since many different cross-linking methods exist, some authors have chosen to compare the effects of multiple cross-linkers on the mechanical properties to determine which methodology is most efficient. Karakecili et al evaluated different cross-linkers including EDAC/NHS, tripolyphosphate, and glyoxal in chitosan and collagen type I composite scaffolds, with results indicating a significant effect of cross-linking method on mechanical strength . The glyoxal cross-linking showed the highest percentage of increase for the compression modulus, whereas EDAC/NHS was found to have the lowest values of the three cross-linkers.…”

Section: Cross-linking For Chitosan Scaffoldsmentioning

confidence: 99%

“…To complement cross-linking with the enhancement of mechanical and osteogenic properties of a scaffold, the addition of apatites and other ceramics is commonly employed. Hydroxyapatite (HA) is one such frequent additive to chitosan-based cross-linked scaffolds. ,,, As a major constituent of natural bone, HA not only increases the mechanical strength of scaffolds but also their biocompatibility and bioactivity …”

Section: Cross-linking For Chitosan Scaffoldsmentioning

confidence: 99%

The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering

Agnes

Karoichan

Tabrizian

2023

ACS Appl. Bio Mater.

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An increasing number of publications over the past ten years have focused on the development of chitosan-based cross-linked scaffolds to regenerate bone tissue. The design of biomaterials for bone tissue engineering applications relies heavily on the ideals set forth by a polytherapy approach called the “Diamond Concept”. This methodology takes into consideration the mechanical environment, scaffold properties, osteogenic and angiogenic potential of cells, and benefits of osteoinductive mediator encapsulation. The following review presents a comprehensive summarization of recent trends in chitosan-based cross-linked scaffold development within the scope of the Diamond Concept, particularly for nonload-bearing bone repair. A standardized methodology for material characterization, along with assessment of in vitro and in vivo potential for bone regeneration, is presented based on approaches in the literature, and future directions of the field are discussed.

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Optimizing Chitosan/Collagen Type I/Nanohydroxyapatite Cross-linked Porous Scaffolds for Bone Tissue Engineering

Cited by 15 publications

References 37 publications

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair

The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering

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