Optimizing control of simulated moving beds—experimental implementation

Abel, Stefanie; Erdem, Gültekin; Amanullah, Mohammad; Morari, Manfred; Mazzotti, Marco; Morbidelli, Massimo

doi:10.1016/j.chroma.2005.04.101

Cited by 59 publications

(50 citation statements)

References 18 publications

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“…Room for optimisation lies in changing flow rates during the switching period, which has been shown to be superior to the classical SMB process in a few case studies [41]. A new control concept to exploit the full potential of the SMB technology [42], experimentally implemented for the first time in the separation of nucleosides, can render the detailed isotherm measurements redundant and save time in the design of the separation. With the use of microscale HPLC for predicting preparative performance and productivity at millionfold scale [43], separations by simulated moving bed chromatography have a great potential to be included in early phase route selections.…”

Section: Discussionmentioning

confidence: 99%

Preparative-scale separation by simulated moving bed chromatography of biocatalytically produced regioisomeric lactones

Kaiser¹,

Ottolina

Carrea

et al. 2009

New Biotechnology

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The separation of enantiomerically pure, but regioisomeric compounds by chromatography is attractive for the production of chiral compounds, if the process leads to high-purity products in high yield with excellent throughput and reduced solvent use. The biocatalytic Baeyer-Villiger oxidation of racemic ketones gives rapid access to an equimolar mixture of regioisomeric lactones with excellent enantiomeric purity. The existing separation methods have so far represented a bottleneck for preparative applications of this technology. Simulated moving bed chromatography is described in this work as an efficient and scalable separation technology able to meet the goals of both high efficiency as well as reduced solvent use. The main factors influencing method optimisation were identified and the parameters of temperature, pressure, weak adsorption, separation factor and robustness were examined with the aim to resolve bottlenecks. Under optimised conditions, the productivity of the process was 0.026g/(g(stationary)(phase) day) of pure regioisomers and the solvent consumption was 0.363L/g(feed).

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Section: Discussionmentioning

confidence: 99%

Preparative-scale separation by simulated moving bed chromatography of biocatalytically produced regioisomeric lactones

Kaiser¹,

Ottolina

Carrea

et al. 2009

New Biotechnology

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“…A more detailed characterization of the system can be found in one of our earlier studies. 20 A linear adsorption isotherm describes the adsorption behavior accurately in the range of feed concentrations investigated in this work. The outlet concentrations of both species were averaged over one cycle and used for control purposes.…”

Section: Experimental Implementationmentioning

confidence: 94%

“…The details about the online monitoring system may be found in earlier publications. 17,20 Case study 1: Plant-model mismatch…”

Section: Experimental Implementationmentioning

confidence: 99%

“…[17][18][19][20][21][22][23] It is noteworthy that this controller requires only minimal information on both, the adsorption behavior of the components to separate, i.e., only the linear adsorption isotherm, and the characteristics of the columns constituting the SMB unit, i.e., only the average void fraction of the columns in the SMB loop. In this control scheme the concentration levels of both species at the extract and raffinate streams are monitored with online optical detectors, i.e., detectors measuring the absorbance of light or the rotation of polarized light, such as UV or polarimeter detectors, respectively.…”

Section: Introductionmentioning

confidence: 99%

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‘Cycle to cycle’ optimizing control of simulated moving beds

Grossmann¹,

Amanullah²,

Erdem³

et al. 2007

AIChE Journal

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in Wiley InterScience (www.interscience.wiley.com).The novel feature of the presented simulated moving bed (SMB) controller is its capability to make use of the average outlet concentration of the product streams over a cycle as feedback information, i.e., 'cycle to cycle' control. Its effectiveness is confirmed experimentally on an eight-column four-section laboratory SMB unit, which is used to separate a binary mixture of the nucleosides, uridine and guanosine. The performance of the 'cycle to cycle' SMB control scheme is also demonstrated by several SMB simulation runs that are chosen to test the robustness of the controller. Furthermore, the case where measurements have a time delay is presented. The results illustrate that the 'cycle to cycle' controller is able to meet the products' purity specifications and operate the process optimally with minimal information about the system regardless of the disturbances that might take place during the operation.Note that Y k contains the concentrations of both species for every time step n 5 0, . . ., N 2 1 of cycle k. Figure 4. Performance of the controller on the laboratory SMB plant for case studies 1 and 2. Outlet purities and cost function vs. time measured in cycles. Feed pump delivers 10% more than its set point after cycle 70. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

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“…489 It was designed to simulate the solid phase movement of the corresponding true moving bed (TMB) process, in which the fluid and solid phases flow counter-currently to each other. 490,491 It continuously separates or purifies feed streams using very much the same chromatography mechanisms, including adsorption, ion exchange, size exclusion, hydrophobic interactions, chiral interactions, affinity, or a combination of these mechanisms. 484 It can effectively separate binary mixtures, i.e., two target compound mixtures, therefore industrial applications to date are often binary separations.…”

Section: Green Chemistry Tutorial Reviewmentioning

confidence: 99%