Optimizing Control of the Hashimoto SMB Process: Experimental Application

Küpper, Achim; Engell, Sebastian

doi:10.3182/20070606-3-mx-2915.00143

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…The controller manages to track the purity reference and to keep the productivity above its lower limits, while it improves the economical operation of the plant by reducing the solvent consumption. The optimizing controller has been implemented at a medium scale SMB plant using a PLC-based process control system and an additional PC for optimization and parameter estimation [102]. A photograph of the setup is shown in Fig.…”

Section: Optimizing Controller Applicationmentioning

confidence: 99%

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Feedback Control for Optimal Process Operation

Engell

2006

IFAC Proceedings Volumes

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122

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Section: Optimizing Controller Applicationmentioning

confidence: 99%

“…Experimental result with the optimizing controller -the controller was started at period 17 and a pump failure occurred during periods 17-24[102].…”

mentioning

confidence: 99%

Feedback Control for Optimal Process Operation

Engell

2006

IFAC Proceedings Volumes

Self Cite

122

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“…Modeling and design of SMBRs have been of great interest in recent years, and many efforts have been made to improve their performance and extend their usage in a wide range of chemical reactions. A significant number of recent studies on SMBR reactors [20][21][22][23][24][25][26][27][28][29][30] are presented in Tab. S1.…”

Section: Introductionmentioning

confidence: 99%

Modeling of the Isomerization and Separation Process of para‐Xylene in a Moving Bed Reactor

2021

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Simulated moving bed reactors (SMBRs) are hybrid reactors that perform reaction and separation processes simultaneously in a single unit. Their high separation performance and ability to overcome equilibrium constraints on the reaction make them effective in a wide range of equilibrium reactions. This study investigated an SMBR for xylene isomerization and separation of p-xylene from other xylene isomers (free of ethylbenzene) in the liquid phase. The effects of operating variables including temperature, switching time, and columns arrangement on the performance parameters and optimal conditions were determined. Due to the removal of products from the reaction site, the SMBR drives the chemical equilibrium toward producing more product than a conventional reactor under the same conditions.

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“…Several variants of the SMB-technology have developed over the years, eSMB, ModiCon, , PowerFlow, , Tandem-SMB, Multizone-SMB e.g. , open 3 zone SMB, Reactive SMB . A special variant of MSB technology that has penetrated production scale of enantiomers is the so-called variable column length (Varicol) technology. , …”

Section: Introductionmentioning

confidence: 99%

Design and Operation of Continuous Countercurrent Chromatography in Biotechnological Production

Zobel

Helling

Ditz

et al. 2014

Ind. Eng. Chem. Res.

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Continuous countercurrent chromatography has been established in industrial operations for over six decades and in fine chemical and pharmaceutical industry since the 1990s. In biotechnological processing, the area where chromatography plays a criticaland often multipleroles, implementation is lacking for various reasons. Options are shown to correct this and make continuous countercurrent chromatography a technologically and economically viable option in GMP-regulated processing. Current approaches, with the exception of MCSGP (multicolumn countercurrent solvent gradient purification), just operate a manifold of 2–6 columns in a sequential but batchwise scheduling. Modifications were made to reduce equipment complexity in GMP-regulated manufacturing and to exploit benefits of countercurrent operation for adsorbent and buffer reduction. A solution with only one column and a minimum of valves, pumps, and buffer vessels was developed. The approach also describes integration of two or more chromatography steps in continuous production, both GMP- and biocompatible.

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Optimizing Control of the Hashimoto SMB Process: Experimental Application

Cited by 12 publications

References 4 publications

Feedback Control for Optimal Process Operation

Feedback Control for Optimal Process Operation

Modeling of the Isomerization and Separation Process of para‐Xylene in a Moving Bed Reactor

Design and Operation of Continuous Countercurrent Chromatography in Biotechnological Production

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