Optimizing GC-ICP-MS for ultra-trace quantification of PBDEs in natural water samples using species-specific isotope dilution

González-Gago, Adriana; Pröfrock, Daniel; Prange, Andreas

doi:10.1039/c4ja00112e

Cited by 22 publications

(6 citation statements)

References 27 publications

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“…It has been shown previously that GC is an excellent sample introduction system for the ICP-MS detection of organophosphorus compounds. ,− Compared to liquid sample introduction into the ICP-MS, the GC delivers dry helium carrier gas containing relatively little matrix. However, GC-ICP-MS is limited to the determination of heteroatom-containing compounds that are volatile and thermally stable or can be converted to a volatile form by derivatizaton before injection into the GC-ICP-MS. Tuning of the GC-ICP-MS/MS was done by substituting the helium carrier gas with 100 ppm of H 2 S spiked in Ar.…”

Section: Resultsmentioning

confidence: 99%

“…However, GC-ICP-MS is limited to the determination of heteroatom-containing compounds that are volatile and thermally stable or can be converted to a volatile form by derivatizaton before injection into the GC-ICP-MS. Tuning of the GC-ICP-MS/MS was done by substituting the helium carrier gas with 100 ppm of H 2 S spiked in Ar. As has already been discussed in the literature, the optimal instrumental parameters for GC-ICP-MS are different from those required under wet plasma conditions. Thus, tuning for optimal parameter settings is required.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of GC-ICP-MS/MS as a New Strategy for Specific Heteroatom Detection of Phosphorus, Sulfur, and Chlorine Determination in Foods

Nelson

Hopfer²,

Silva

et al. 2015

J. Agric. Food Chem.

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For the first time in the literature, application of a GC-ICP-MS/MS method for the selective and sensitive detection of specific heteroatoms of phosphorus, sulfur, and chlorine has been accomplished. As a proof of concept, organophosphorus, organosulfur, and organochlorine pesticides in various food matrices have been studied. For the detection of organophosphorus and organosulfur pesticides, oxygen was used in the collision reaction cell (CRC) to convert P (m/z 31) to PO(+) (m/z 47) and S (m/z 32) to SO(+) (m/z 48). Similarly, ClH2(+) (m/z 37) was monitored after the reaction of Cl (m/z 35) with hydrogen in the CRC for the determination of organochlorine pesticides. Real food samples (baby food purees, fresh vegetables, loose tea) were screened for their pesticide content, following preparation of triplicate extracts using QuEChERS (quick, easy, cheap, effective, rugged, and safe). Excellent linearity with correlation coefficients R ≥ 0.997 was achieved, and the lowest detection limits obtained for the organophosphorus, organosulfur, and organochlorine pesticides were 0.0005, 0.675, and 0.144 μg/kg, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Evaluation of GC-ICP-MS/MS as a New Strategy for Specific Heteroatom Detection of Phosphorus, Sulfur, and Chlorine Determination in Foods

Nelson

Hopfer²,

Silva

et al. 2015

J. Agric. Food Chem.

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“…It is important to note that different LODs arise from variations in chromatographic peak shapes and do not contradict the compoundindependent response based on peak areas. In comparison, elemental LODs of ∼10 pg for fluorine, 23 0.1-0.2 pg for chlorine 26,27 and 0.04 pg for bromine 28 have been reported using other plasma-based ionization methods coupled to GC. While PARCI's sensitivity for Cl and Br is comparable to that reported using state-of-the-art elemental MS instruments, about one order of magnitude better detection for fluorine is offered by PARCI.…”

Section: Linearity and Limits Of Detectionmentioning

confidence: 91%

High-sensitivity elemental ionization for quantitative detection of halogenated compounds

Wang

Minardi

Badiei

et al. 2015

Analyst

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The rising importance of organohalogens in environmental, pharmaceutical, and biological applications has drawn attention to analysis of these compounds in recent years. Elemental mass spectrometry (MS) is particularly advantageous in this regard because of its ability to quantify without compound-specific standards. However, low sensitivity of conventional elemental MS for halogens has hampered applications of this powerful method in organohalogen analyses. To this end, we have developed a high-sensitivity elemental ion source compatible with widely available atmospheric-sampling mass spectrometers. We utilize a helium-oxygen plasma for atomization followed by negative ion formation in plasma afterglow, a configuration termed as plasma-assisted reaction chemical ionization (PARCI). The effect of oxygen on in-plasma and afterglow reactions is investigated, leading to fundamental understanding of ion generation processes as well as optimized operating conditions. Coupled to a gas chromatograph, PARCI shows constant ionization efficiency for F, Cl, and Br regardless of the chemical structure of the compounds. Negative ionization in the afterglow improves halide ion formation efficiency and eliminates isobaric interferences, offering sub-picogram elemental detection for F, Cl, and Br using low-resolution MS. Notably, the detection limit for F is about one order of magnitude better than other elemental MS techniques. The high sensitivity and facile adoptability of PARCI pave the way for combined elemental-molecular characterization, a comprehensive analytical scheme for rapid identification and quantification of organohalogens.

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“…The former has been investigated in various studies and is accomplished by employing hard extraction conditions, which are applied in sector-field-based ICP-MS setups but also in combination with cool and dry plasmas in quadrupole-based GC-ICP-MS and LA-ICP-MS . During hard extraction, the polarity of the first extraction lens is reversed to highly negative potentials (e.g., −200 V, Table ), whereas the second extraction lens is operated closer to the ground potential (e.g., −6 V, Table ) to increase the kinetic energy of ions . This results in a more efficient ion extraction and transport, which simultaneously mitigates space charge effects.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass

Meyer

Vega

et al. 2020

Anal. Chem.

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This work introduces new methods to characterize dispersions of small-diameter or low-mass-fraction nanoparticles (NPs) by single-particle inductively coupled plasma-mass spectrometry (SP ICP-MS). The optimization of ion extraction, ion transport, and the operation of the quadrupole with increased mass bandwidth improved the signal-to-noise ratios significantly and decreased the size detection limits for all NP dispersions investigated. As a model system, 10.9 ± 1.0 nm Au NPs were analyzed to demonstrate the effects of increasing ion transmission. Specifically, increasing the mass bandwidth of the quadrupole improved the size detection limit to 4.2 nm and enabled the resolution of NP signals from ionic background and noise. Subsequently, the methods were applied to the characterization of lanthanide-doped upconversion nanoparticles (UCNPs) by SP ICP-MS. Three different types of UCNPs (90 nm NaYF4: 20% Yb, 2% Er; 20 nm NaGdF4: 20% Yb, 1% Er; 15 nm NaYF4: 20% Yb, 2% Er) were investigated. Y showed the best signal-to-noise ratios with optimized ion extraction and transport parameters only, whereas the signal-to-noise ratios of Gd, Er, and Yb were further improved by increasing the mass bandwidth of a quadrupole mass filter. The novel methods were suitable for detailed characterization of diluted UCNP dispersions including particle stoichiometries and size distributions. A Poisson model was further applied to assess particle–particle interactions in the aqueous dispersions. The methods have considerable potential for the characterization of small-diameter and/or low-mass-fraction nanoparticles.

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Optimizing GC-ICP-MS for ultra-trace quantification of PBDEs in natural water samples using species-specific isotope dilution

Abstract: A new approach based on the use of GC-ICP-MS and 81Br-labelled PBDEs for species-specific isotope dilution has been developed for the reliable quantification of PBDEs according to the EU WFD.

Cited by 22 publications

References 27 publications

Evaluation of GC-ICP-MS/MS as a New Strategy for Specific Heteroatom Detection of Phosphorus, Sulfur, and Chlorine Determination in Foods

Evaluation of GC-ICP-MS/MS as a New Strategy for Specific Heteroatom Detection of Phosphorus, Sulfur, and Chlorine Determination in Foods

High-sensitivity elemental ionization for quantitative detection of halogenated compounds

Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass

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