Optimizing Hand-held Spectral Domain Optical Coherence Tomography Imaging for Neonates, Infants, and Children

Maldonado, Ramiro S.; Izatt, Joseph A.; Sarin, Neeru; Wallace, David K.; Freedman, Sharon F.; Cotten, C. Michael; Toth, Cynthia A.

doi:10.1167/iovs.09-4403

Cited by 209 publications

(216 citation statements)

References 38 publications

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“…The development of a handheld SD-OCT has enabled pediatric practitioners to acquire high resolution images of the circumpapillary RNFL and macula in neonates, infants and young children. [13][14][15][16][17][18][19][20][21][22][23][24] While neonates and infants can be imaged while awake, the portability of the handheld OCT permits acquisition in toddlers and young children during sedation.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Avery¹,

Cnaan²,

Schuman³

et al. 2014

Journal of American Association for Pediatric Ophthalmology and

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Section: Introductionmentioning

confidence: 99%

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Avery¹,

Cnaan²,

Schuman³

et al. 2014

Journal of American Association for Pediatric Ophthalmology and

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“…3 Optical coherence tomography (OCT) is a noninvasive technique for high-resolution crosssectional tomographic imaging of the retina and optic nerve head. 4 Although the retinal nerve fiber layer (RNFL) and macular thickness have been Purpose: To compare the macular and nerve fi ber layer thicknesses as measured by optical coherence tomography (OCT) in amblyopic and fellow eyes.…”

Section: Introductionmentioning

confidence: 99%

Macular and Retinal Nerve Fiber Layer Thickness in Unilateral Anisometropic or Strabismic Amblyopia

Andalib

Javadzadeh²,

Nabai³

et al. 2013

J Pediatr Ophthalmol Strabismus

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Purpose: To compare the macular and nerve fiber layer thicknesses as measured by optical coherence tomography (OCT) in amblyopic and fellow eyes. Methods: Fifty patients with monocular strabismic (n = 25) or anisometropic (n = 25) amblyopia (best corrected visual acuity (BCVA) ranging from 20/40 to 20/400) were included in a prospective cross-sectional descriptive study. A refractive error more than 5 diopters in either eye or an axial length difference between the eyes of more than 1 mm was excluded in the anisometropic group. In all cases, the thickness of the macular area and the peripapillary nerve fiber layer were measured by OCT in both amblyopic and fellow eyes and compared with each other. Results: The mean age of patients was 10 ± 3.1 years (range: 6 to 18 years) in the anisometropic group and 8.9 ± 3.7 years (range: 6 to 18 years) in the strabismic group. In the anisometropic group, the mean macular thickness was significantly increased in the amblyopic eyes (222.6 ± 47.8 μm) versus the fellow eyes (205.6 ± 33.3 μm) ( P = .002), although there was no significant difference observed when comparing with the prepapillary nerve fiber layer ( P = .55). There was no significant correlation of above-mentioned matters in the strabismic group ( P = .07 and .52). Conclusion: A thicker macula was found in anisometropic amblyopic eyes, but the increase of macular thickness in strabismic amblyopic eyes was not significant. Retinal involvement was not observed in the peripapillary nerve fiber layer of amblyopic eyes. [J Pediatr Ophthalmol Strabismus 2013;50(4):218–221.]

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“…1 Hand-held OCT is well tolerated by children and infants, and is more sensitive than clinical examination in detecting macular pathology. 2,3 OCT has been used to identify clinically important retinal pathologies in premature infants, including retinoschisis, [4][5][6] foveal hypoplasia, 6,7 intraretinal cysts, 6,8 preretinal neovascularization, 5,9 and retinal detachment. 5,10 Macular holes, 11 hemorrhagic retinoschisis, 12,13 vitreoretinal traction and epiretinal membranes 11,12 were identified in Shaken Baby Syndrome using OCT, and in some cases influenced surgical management.…”

Section: Introductionmentioning

confidence: 99%

“…16 While hand-held SD-OCT may be performed during examination under anesthesia, anesthesia is not necessary to obtain useful images in infants and cooperative children. 2 Establishing a normative database of SD-OCT findings in healthy full term newborn infants is an important prerequisite for the proper diagnosis of retinal pathology using SD-OCT in this population. We are not aware of any report on SD-OCT imaging of healthy full term neonates to date (PubMed Mesh search terms: Optical coherence tomography AND Infant).…”

Section: Introductionmentioning

confidence: 99%

Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

Cabrera¹,

O’Connell²,

Toth³

et al. 2012

Journal of American Association for Pediatric Ophthalmology and

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Purpose-To report retinal findings for healthy newborn infants imaged with hand held Spectral Domain Optical Coherence Tomography (SD-OCT). Design-Prospective observational case series.Methods-Thirty-nine full term newborn infants had dilated retinal examinations by indirect ophthalmoscopy and retinal imaging by handheld SD-OCT, without sedation, at the Duke Birthing Center.Results-Of the 39 infants imaged, 44% (17/39) were male. Race/ethnicity composition was 56% white, 38% black, 3% Asian, and 3% Hispanic. Median gestational age was 39 weeks (range 36 to 41). Six of the 39 infants (15%) had bilateral subfoveal fluid on SD-OCT not seen by indirect ophthalmoscopy. Eight infants (21%) had retinal hemorrhages noted on dilated retinal examination, 1 of which had subretinal fluid on SD-OCT. Subretinal fluid was noted on follow up examination to have resolved on SD-OCT 1 to 4 months later. Infants with bilateral subretinal fluid had an older gestational age compared to infants without subretinal fluid (median 40.4 vs. 39.1 weeks, respectively, P=0.03) and were more likely to have had mothers with diabetes (2/6 vs. 0/33, respectively, P=0.02). Vaginal versus C-section delivery was not significantly different between the two groups.Conclusions-Some healthy full term infants have bilateral subfoveal fluid not obvious on dilated retinal examination. This fluid resolves within several months. The visual significance of this finding is unknown, but clinicians should be aware it is common when evaluating newborn infants for retinal pathology using SD-OCT.

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Optimizing Hand-held Spectral Domain Optical Coherence Tomography Imaging for Neonates, Infants, and Children

Abstract: SD OCT in young children and neonates should be customized for the unique optical parameters of the infant eye. This customization, not only improves image quality, but also allows control of the density of the optical sampling directed onto the retina.

Cited by 209 publications

References 38 publications

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Macular and Retinal Nerve Fiber Layer Thickness in Unilateral Anisometropic or Strabismic Amblyopia

Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

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