Optimizing Hepatitis C Virus Inhibitor Identification with LightGBM and Tree-structured Parzen Estimator Sampling
Teuku Rizky Noviandy,
Ghifari Maulana Idroes,
Aga Maulana
et al.
Abstract:Identifying potent inhibitors against the Hepatitis C Virus (HCV) is crucial due to the continuous emergence of drug-resistant strains. Traditional drug discovery methods, including high-throughput screening, are often resource-intensive and time-consuming. Machine Learning (ML) approaches, particularly Quantitative Structure-Activity Relationship modeling, have been increasingly adopted to address this. This study utilized LightGBM, an efficient gradient-boosting framework, to predict the activity of potentia… Show more
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