Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks

Hinkley, Leighton B.; Witte, Elke De; Cahill-Thompson, Megan; Mizuiri, Danielle; Garrett, Coleman; Honma, Susanne; Findlay, Anne; Gorno‐Tempini, Maria Luisa; Tarapore, Phiroz E.; Kirsch, Heidi E.; Mariën, Peter; Houde, John F.; Berger, Mitchel S.; Nagarajan, Srikantan S.

doi:10.3389/fnhum.2020.00105

Cited by 13 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimuli varied in concreteness (e.g., "ball" versus "music"), familiarity (e.g., "store" versus "knob"), and imageability (e.g., "car" versus "story"). E-Prime 1 was used to deliver the stimuli via headphones and verbal responses were spoken into a microphone and recorded for post-processing analysis (Findlay et al, 2013;Hinkley et al, 2020). The task was performed during MEG recordings as part of a large protocol studying language processing dynamics in PPA patients (Borghesani et al, 2020b(Borghesani et al, , 2021, however, the current study focused on fine-grained analysis of the behavioral performance during the verb generation task.…”

Section: Behavioral Data Acquisitionmentioning

confidence: 99%

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia

et al. 2022

Self Cite

View full text Add to dashboard Cite

Primary progressive aphasia (PPA) is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic (lvPPA), associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic (svPPA), associated with semantic deficits and anterior temporal lobe (ATL) atrophy; non-fluent (nfvPPA) associated with grammar and/or speech-motor deficits and inferior frontal gyrus (IFG) atrophy. Here, we set out to investigate whether the three variants of PPA can be dissociated based on error patterns in a single language task. We recruited 21 lvPPA, 28 svPPA, and 24 nfvPPA patients, together with 31 healthy controls, and analyzed their performance on an auditory noun-to-verb generation task, which requires auditory analysis of the input, access to and selection of relevant lexical and semantic knowledge, as well as preparation and execution of speech. Task accuracy differed across the three variants and controls, with lvPPA and nfvPPA having the lowest and highest accuracy, respectively. Critically, machine learning analysis of the different error types yielded above-chance classification of patients into their corresponding group. An analysis of the error types revealed clear variant-specific effects: lvPPA patients produced the highest percentage of “not-a-verb” responses and the highest number of semantically related nouns (production of baseball instead of throw to noun ball); in contrast, svPPA patients produced the highest percentage of “unrelated verb” responses and the highest number of light verbs (production of take instead of throw to noun ball). Taken together, our findings indicate that error patterns in an auditory verb generation task are associated with the breakdown of different neurocognitive mechanisms across PPA variants. Specifically, they corroborate the link between temporo-parietal regions with lexical processing, as well as ATL with semantic processes. These findings illustrate how the analysis of pattern of responses can help PPA phenotyping and heighten diagnostic sensitivity, while providing insights on the neural correlates of different components of language.

show abstract

Section: Behavioral Data Acquisitionmentioning

confidence: 99%

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Secondly, it is likely that using TMS frequencies matching with the natural frequency band of endogenous brain oscillations increases the probability of TMS pulses to interfere with cortical processing at the appropriate timing ( Thut and Miniussi, 2009 ; Miniussi et al, 2013 ; Nettekoven et al, 2021 ). Indeed, evidence from MEG studies has associated language-related processing with brain oscillations in higher frequency bands, such as the beta (17–25 Hz) and the low gamma band (26–50 Hz) ( Hirata et al, 2010 ; Hinkley et al, 2020 ; Youssofzadeh et al, 2020 ). It is also worth noting that different language brain regions may be sensitive to different stimulation frequencies.…”

Section: Discussionmentioning

confidence: 99%

Neuromodulatory effects of transcranial magnetic stimulation on language performance in healthy participants: Systematic review and meta-analysis

Wang

Cheng

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

BackgroundThe causal relationships between neural substrates and human language have been investigated by transcranial magnetic stimulation (TMS). However, the robustness of TMS neuromodulatory effects is still largely unspecified. This study aims to systematically examine the efficacy of TMS on healthy participants’ language performance.MethodsFor this meta-analysis, we searched PubMed, Web of Science, PsycINFO, Scopus, and Google Scholar from database inception until October 15, 2022 for eligible TMS studies on language comprehension and production in healthy adults published in English. The quality of the included studies was assessed with the Cochrane risk of bias tool. Potential publication biases were assessed by funnel plots and the Egger Test. We conducted overall as well as moderator meta-analyses. Effect sizes were estimated using Hedges’g (g) and entered into a three-level random effects model.ResultsThirty-seven studies (797 participants) with 77 effect sizes were included. The three-level random effects model revealed significant overall TMS effects on language performance in healthy participants (RT: g = 0.16, 95% CI: 0.04–0.29; ACC: g = 0.14, 95% CI: 0.04–0.24). Further moderator analyses indicated that (a) for language tasks, TMS induced significant neuromodulatory effects on semantic and phonological tasks, but didn’t show significance for syntactic tasks; (b) for cortical targets, TMS effects were not significant in left frontal, temporal or parietal regions, but were marginally significant in the inferior frontal gyrus in a finer-scale analysis; (c) for stimulation parameters, stimulation sites extracted from previous studies, rTMS, and intensities calibrated to the individual resting motor threshold are more prone to induce robust TMS effects. As for stimulation frequencies and timing, both high and low frequencies, online and offline stimulation elicited significant effects; (d) for experimental designs, studies adopting sham TMS or no TMS as the control condition and within-subject design obtained more significant effects.DiscussionOverall, the results show that TMS may robustly modulate healthy adults’ language performance and scrutinize the brain-and-language relation in a profound fashion. However, due to limited sample size and constraints in the current meta-analysis approach, analyses at a more comprehensive level were not conducted and results need to be confirmed by future studies.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=366481], identifier [CRD42022366481].

show abstract

“…Given some of the advantages of MEG over fMRI in patients with glioma, at some centers, MEG has become the preferred preoperative functional imaging modality. MEG has been used to determine laterality preoperatively ( Findlay et al, 2012 ; Hinkley et al, 2020 ) and demonstrates good spatial concordance with DES for functional language sites ( Frye et al, 2009 ; Hirata et al, 2010 ). Moreover, there is evidence that MEG can play a complementary role to DES, especially in the white matter.…”

Section: Invasive and Non-invasive Techniques For Mapping And Preserv...mentioning

confidence: 99%

Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury

et al. 2022

View full text Add to dashboard Cite

To achieve optimal survival and quality of life outcomes in patients with glioma, the extent of tumor resection must be maximized without causing injury to eloquent structures. Preservation of language function is of particular importance to patients and requires careful mapping to reveal the locations of cortical language hubs and their structural and functional connections. Within this language network, accurate mapping of eloquent white matter tracts is critical, given the high risk of permanent neurological impairment if they are injured during surgery. In this review, we start by describing the clinical implications of gliomas involving white matter language tracts. Next, we highlight the advantages and limitations of methods commonly used to identify these tracts during surgery including structural imaging techniques, functional imaging, non-invasive stimulation, and finally, awake craniotomy. We provide a rationale for combining these complementary techniques as part of a multimodal mapping paradigm to optimize postoperative language outcomes. Next, we review local and long-range adaptations that take place as the language network undergoes remodeling after tumor growth and surgical resection. We discuss the probable cellular mechanisms underlying this plasticity with emphasis on the white matter, which until recently was thought to have a limited role in adults. Finally, we provide an overview of emerging developments in targeting the glioma-neuronal network interface to achieve better disease control and promote recovery after injury.

show abstract

Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks

Cited by 13 publications

References 48 publications

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia

Neuromodulatory effects of transcranial magnetic stimulation on language performance in healthy participants: Systematic review and meta-analysis

Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury

Contact Info

Product

Resources

About