Optimizing microenvironment by integrating negative pressure and exogenous electric fields <i>via</i> a flexible porous conductive dressing to accelerate wound healing

Chen, Ying; Liang, Yi; Liu, Jie; Yang, Jinrui; Jia, Naixin; Zhu, Chuhong; Zhang, Jiaping

doi:10.1039/d0bm01172j

Cited by 31 publications

(25 citation statements)

References 51 publications

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“…The electrical stimulation devices commonly used in clinical treatment are mostly traditional electrical stimulation devices. Traditional electrical stimulation devices are mainly power devices that can generate different types of currents, such as DC power supplies (output DC), [ 38,48 ] signal generators (output AC and PC), [ 43,44,52 ] etc. Although they have achieved good results when applied to wounds, the traditional electrical stimulation devices are relatively large and difficult to carry around.…”

Section: Electrical Stimulation Treatment Devices and Methods For Skin Wound Healingmentioning

confidence: 99%

Accelerated Skin Wound Healing by Electrical Stimulation

Luo

Dai

Zhang

et al. 2021

Adv Healthcare Materials

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256

134

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When the integrity of the skin got damaged, an endogenous electric field will be generated in the wound and a series of physiological reactions will be initiated to close the wound. The existence of the endogenous electric field of the wound has a promoting effect on all stages of wound healing. For wounds that cannot heal on their own, the exogenous electric field can assist the treatment. In this review, the effects of exogenous electrical stimulation on wound healing, such as the inflammation phase, blood flow, cell proliferation and migration, and the wound scarring is overviewed. This article also reviews the new electrical stimulation methods that have emerged in recent years, such as small power supplies, nanogenerators (NGs), and other physical, chemical or biological strategies. These new electrical stimulation methods and devices are safe, low‐cost, stable, and small in size. The challenge and perspective are discussed for the future trends of the electrical stimulation treatment in accelerating skin wound healing.

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Section: Electrical Stimulation Treatment Devices and Methods For Skin Wound Healingmentioning

confidence: 99%

Accelerated Skin Wound Healing by Electrical Stimulation

Luo

Dai

Zhang

et al. 2021

Adv Healthcare Materials

Self Cite

256

134

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“…Swelling is an essential property of cryogels, enabled the cryogels to absorb excessive exudate of the wound, and provide a moist environment bene cial to wound healing [40][41][42]. Also, the porous structure is conducive to cell migration and provides excellent oxygen permeability, which could accelerate wound healing [43,44]. Therefore, the swelling ratios of cryogels were evaluated, and the results are shown in Figure 2L.…”

Section: Resultsmentioning

confidence: 99%

Development of Tannin-bridged Cerium Oxide Microcubes-chitosan Cryogel as a Multifunctional Wound Dressing

Teng¹,

Li²,

Lu³

et al. 2021

Preprint

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Background: Efficient resolution of oxidative stress, inflammation and bacterial infections are crucial for wound healing. To surmount these problems, tannic acid (TA)-bridged CeO2 microcubes and chitosan (CS) (CS-TA@CeO2) cryogel was fabricated through hydrogen bonding interactions as a multifunctional wound dressing. Results: The physicochemical characterizations confirmed the successful introduction and uniform incorporation of TA@CeO2 microcubes into CS network. Thus-obtained CS-TA@CeO2 cryogels displayed suitable porous structure and swelling ratio. The CS-TA@CeO2 cryogels exhibited favorable antioxidant ability evidenced by scavenging more than 82.9% ROS in vitro and significantly increasing the antioxidant enzyme levels in vivo. The anti-inflammatory ability of the cryogels was confirmed by the downregulated expression of the inflammatory cytokine, tumor necrosis factor-alpha (TNF-α) and the upregulated expression of the anti-inflammatory cytokine, interleukin-10 (IL-10). The multifunctional cryogels also showed excellent antibacterial activities against Gram-positive (S.aureus) and Gram-negative (E.coli) bacteria. Furthermore, the cryogels can promote the adhesion and proliferation of mouse fibroblasts (L929) cells. Moreover, CS-TA@CeO2 cryogels presented excellent hemostatic performance in rat tail amputation model. In vivo Sprague-Dawley (SD) rats full-thickness experiments illustrated that the cryogels can significantly accelerate wound healing through providing considerable antioxidant activity, promoting angiogenesis, and increasing collagen deposition. Conclusions: Overall, the multifunctional CS-TA@CeO2 cryogels showed great potential for wound healing.

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“…3D conductive biomaterials demonstrate promising potential in electrodes for electrotherapy and scaffolds for skin tissue engineering. Chen et al reported an Ag nanowires-loaded foam demonstrating flexibility, enhanced conductivity, and long-term stability under physiological environment [ 226 ]. Due to the inherent antibacterial activity, good water-uptake capability, and electrical conductivity, the conductive foam could not only prevent infection and manage necrosis, but also implement annular oriented electrical field to wounds assisted by exogenous electrical fields.…”

Section: D Conductive Biomaterials For Wound Healingmentioning

confidence: 99%

“…First, they can be applied as compliant electrodes for electrotherapy. In general, the conductive wound dressings can facilitate ES to be well and uniformly conducted onto the wounds promoting the efficacy of electrotherapy [ 50 , 109 , 120 , 225 , 226 ]. Second, they can be used alone as wound dressings or tissue engineering scaffolds, demonstrating similar conductivity to human skin and supporting cellular activities, to accelerate wound healing performance.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

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Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.

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Optimizing microenvironment by integrating negative pressure and exogenous electric fields via a flexible porous conductive dressing to accelerate wound healing

Abstract: Integrated directional exogenous electric field and negative pressure wound therapy via Ag nanowire polyurethane foam dressing to accelerate wound healing in pig model.

Cited by 31 publications

References 51 publications

Accelerated Skin Wound Healing by Electrical Stimulation

Accelerated Skin Wound Healing by Electrical Stimulation

Development of Tannin-bridged Cerium Oxide Microcubes-chitosan Cryogel as a Multifunctional Wound Dressing

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

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