Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineering

Lowe, Baboucarr; Hardy, John G.; Walsh, L. J.

doi:10.1021/acsomega.9b02917

Cited by 94 publications

(57 citation statements)

References 48 publications

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“…In order to regenerate bone, bone tissue engineering requires the use of materials with functional properties, and nano-HAp holds great promise for biological effects [ 56 ], for example, nanoparticles can optimise interactions with bone proteins and proper nanoparticle shape can achieve a special control on cell behaviour. Moreover, the resorption rate of composite materials can be modified by changes in crystallinity and composition of nano-HAp, fitting in this way the bone formation rate.…”

Section: Resultsmentioning

confidence: 99%

In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

Antoniac

Vasile

et al. 2021

Bioactive Materials

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New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous tissues. Taking inspiration from basic composition of the mammalian bones, composed of collagen, apatite and a number of substitution ions, among them magnesium (Mg 2+ ), in this work, novel composite scaffolds composed of collagen(10%)-hydroxyapatite (HAp)(90%) and collagen(10%)-HAp(80%)-Mg(10%) were developed. The lyophilization was used for composites preparation. An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray. The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils. The samples were tested for degradation in Simulated Body Fluid (SBF) solution by soaking for up to 28 days. The release of Mg from collagen(10%)-HAp(80%)-Mg(10%) composite during the period of up to 21 days was attested, this composite being characterized by a decreased degradation rate with respect to the composite without Mg. The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.

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Section: Resultsmentioning

confidence: 99%

In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

Antoniac

Vasile

et al. 2021

Bioactive Materials

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“…33 Concerning the concentration of the precursors, low concentrations were used to promote the precipitation of HAp and minimize the precipitation of other CaP phases. According to Recillas et al, 34 in addition to low concentration of Ca 2+ and PO 4 3− ions, a pH higher than 6 is also desired to promote selective www.soci.org A Veiga et al…”

Section: Resultsmentioning

confidence: 99%

“…In particular, small size and non-stoichiometry of nano-HAp contribute to a higher reactivity, recognized as advantageous for bone integration and regeneration. [2][3][4] Synthesis of nano-HAp/organic composites is a well-establish approach for obtaining biomaterials that resemble bone tissue. 5 Moreover, the study of these inorganic/inorganic composite structures is particularly relevant for understanding bone biomineralization.…”

Section: Introductionmentioning

confidence: 99%

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High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites

Veiga

Castro

Oliveira

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND: Sericin (SS) induces nucleation of bone-like hydroxyapatite (HAp) when used as an organic matrix. HAp/SS nanocomposites have been conventionally synthesized through precipitation in stirred tank reactors (STs). Despite its simplicity, this process is time consuming and presents difficulties in scale-up. In our study, HAp/SS nanocomposites were successfully synthesized in a ST and in a meso-oscillatory flow reactor (meso-OFR), to compare the efficiency of both reactors and to study HAp mineralization using SS as a template. RESULTS: The production of stable HAp, indicated by pH stabilization, was achieved after 180 min in the ST and after 30 min in the meso-OFR. X-ray diffraction and Fourier transform infrared analyses showed that the particles obtained in both reactors are HAp/SS nanocomposites with low crystallinity. Scanning electron microscopy evidenced the formation of rod-and plateshaped nanoparticles and revealed that the presence of SS led to the production of larger particles. The latter observation was confirmed by laser diffraction. Additionally, increasing SS concentration resulted in the formation of more plate-like particles. CONCLUSIONS: Precipitation is more efficient in the meso-OFR, HAp/SS being obtained four times faster. The presence and concentration of SS led to differences in the size and morphology of the synthesized particles, suggesting a critical role of SS in the mineralization process. This work reports a new approach for the manufacture of high-added-value nanocomposites with similar characteristics to biological bone and the results of a study of the influence of SS as an organic component in HAp nucleation. Further, the use of this protein and technology leads to significant waste minimization.

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“…Furthermore, they enhance cell adhesion augmenting the adsorption of extracellular matrix proteins on their surface (103). Calcium phosphate molecules can be manufactured as macro-sized molecules or nano-sized molecules (104)(105)(106). Despite many advantages of these coatings, there are several disadvantages, such as inferior mechanical stability (98).…”

Section: Factors Positively Affecting Osseointegrationmentioning

confidence: 99%

Bone and Cartilage Interfaces With Orthopedic Implants: A Literature Review

et al. 2020

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The interface between a surgical implant and tissue consists of a complex and dynamic environment characterized by mechanical and biological interactions between the implant and surrounding tissue. The implantation process leads to injury which needs to heal over time and the rapidity of this process as well as the property of restored tissue impact directly the strength of the interface. Bleeding is the first and most relevant step of the healing process because blood provides growth factors and cellular material necessary for tissue repair. Integration of the implants placed in poorly vascularized tissue such as articular cartilage is, therefore, more challenging than compared with the implants placed in well-vascularized tissues such as bone. Bleeding is followed by the establishment of a provisional matrix that is gradually transformed into the native tissue. The ultimate goal of implantation is to obtain a complete integration between the implant and tissue resulting in long-term stability. The stability of the implant has been defined as primary (mechanical) and secondary (biological integration) stability. Successful integration of an implant within the tissue depends on both stabilities and is vital for short- and long-term surgical outcomes. Advances in research aim to improve implant integration resulting in enhanced implant and tissue interface. Numerous methods have been employed to improve the process of modifying both stability types. This review provides a comprehensive discussion of current knowledge regarding implant-tissue interfaces within bone and cartilage as well as novel approaches to strengthen the implant-tissue interface. Furthermore, it gives an insight into the current state-of-art biomechanical testing of the stability of the implants. Current knowledge reveals that the design of the implants closely mimicking the native structure is more likely to become well integrated. The literature provides however several other techniques such as coating with a bioactive compound that will stimulate the integration and successful outcome for the patient.

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Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineering

Cited by 94 publications

References 48 publications

In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites

Bone and Cartilage Interfaces With Orthopedic Implants: A Literature Review

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