U-turn behavior of vehicle is one of the main causes of urban traffic congestion and accidents. A collaborative U-turn merging control algorithm is studied with collision avoidance and delay minimization for vehicles under Cooperative Vehicle Infrastructure System (CVIS) environment. Two control strategies, zip merging and platoon merging control, are proposed. e applicability of these two strategies is compared from the perspective of efficiency and driving comfort. e cellular automaton simulation system composed of a two-way four-lane traffic flow with a U-turn facility in middle of road is established with cooperative control algorithm imbedded. e influence of cooperative U-turn merging behaviors on traffic performance is evaluated by analyzing the arrival rates of main lane and U-turn vehicles and their relationship between one another. e simulation results show that the arrival rate of vehicles on target lane has a great impact on traffic delay. e cooperative control can improve the traffic flow only in the condition that the arrival rate of vehicles on target lane is less than 0.7. It provides some practical references for transportation agencies to meet efficiency requirements of the U-turn section when they apply cooperative control strategy.