Optimizing specimen collection and laboratory procedures reduces the non‐diagnostic rate for endoscopic ultrasound‐guided fine‐needle aspiration of solid lesions of the pancreas

Weynand, Birgit; Borbath, Ivan; Galant, Christine; Piessevaux, Hubert; Deprez, Pierre Henri

doi:10.1111/j.1365-2303.2011.00924.x

Cited by 28 publications

(21 citation statements)

References 33 publications

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“…Previous studies have reported a EUS-FNA sensitivity between 80% and 90% [6,[11][12][13].The cytological yield in our series improved from 59% between 2003 and 2007 to 80.7% between 2008 and 2011. The improvement in our figures is possibly due a combination of the following factors: increased awareness among endosonographers and cytopathologists, use of LBC for processing and increasing the number of categorical diagnosis by reducing the number of samples categorised as atypical or suspicious [21][22][23].…”

Section: Discussionmentioning

confidence: 87%

Diagnostic Performance of Endoscopic Ultrasound (EUS)/ Endoscopic Ultrasound – Fine Needle Aspiration (EUS-FNA) Cytology in Solid and Cystic Pancreatic Neuroendocrine Tumours

Mitra¹,

Nayar²,

Leeds³

et al. 2015

JGLD

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Background & Aims: Our study aimed to assess the sensitivity of EUS and EUS-FNA for pancreatic neuro-endocrine tumors (pNETs) and compare performance over two consecutive 4 year 2 month periods, to investigate the comparative performance between solid and cystic pNETs and determine the incremental yield of EUS±FNA in individuals with a mass not diagnosed as a pNET after cross-sectional imaging.Methods: A retrospective review of a prospectively maintained database was carried out to identify all pNET patients who underwent EUS-FNA between April 2003 and September 2011.Results: A final diagnosis of solid and cystic pNETs was made in 43 and 10 patients, respectively. Overall, the yield of combined EUS imaging and cytology was significantly higher than that of CT and/or MRI (p< 0.05) across all groups [solid (83.7% vs. 41.8%), cystic (70% vs. 10%) and combined solid-cystic (81.1% vs. 35.8%)]. The yield of combined EUS imaging and cytology was significantly better than EUS imaging alone (p<0.05) in the solid (83.7% vs. 58%) and combined pNET cohort (81.1% vs. 52.8%) of patients. After a non-diagnostic CT and or MRI, EUS/EUS-FNA confirmed pNET in 19 out of 25 patients (76.0%) with solid pNETs and 6 out of 9 patients (66.7%) with cystic pNETs.Conclusion: EUS and EUS-FNA had a significant clinical impact in the 25/34 of cases where pNET was not suspected after initial cross-sectional imaging.

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Section: Discussionmentioning

confidence: 87%

Diagnostic Performance of Endoscopic Ultrasound (EUS)/ Endoscopic Ultrasound – Fine Needle Aspiration (EUS-FNA) Cytology in Solid and Cystic Pancreatic Neuroendocrine Tumours

Mitra¹,

Nayar²,

Leeds³

et al. 2015

JGLD

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“…As imaging techniques advance, some argue that there is no longer a need for rapid evaluation for specimen adequacy, especially in hospitals where this may be logistically difficult [6]. Indeed, some have even proposed methods for optimizing laboratory procedures in order to increase the diagnostic accuracy without using rapid evaluation [7]. Most studies agree, however, that ROSE is vital to optimize patient sample adequacy [8,9,10].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology of Porta Hepatis Lesions: A Retrospective Study

Jones

Biederman²,

Draganova‐Tacheva³

et al. 2016

Acta Cytologica

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Objective: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has recently been used for the evaluation of various lesions arising in the porta hepatis. The purpose of this study is to evaluate the diagnostic yield of this increasingly utilized approach to porta hepatis lesions. Study Design: A retrospective study of 72 consecutive samples of porta hepatis lesions obtained via EUS-FNA between 2004 and 2015 was conducted. Clinical histories and endoscopic findings were available prior to the diagnostic interpretation. The diagnosis of each lesion was based on its cytologic features on smears, its histologic features on cell block, a comparison with any relevant prior specimens, immunohistochemistry and flow cytometric studies when applicable. Results: A total of 72 lesions (59 lymph nodes, 2 cysts and 11 masses) were biopsied in 70 patients. Adequate specimens were obtained in 65/72 cases (90%). Most of the lymph nodes were benign (n = 40, 67%) and most of the masses were malignant or suspicious (n = 8, 73%). A variety of diagnoses, primary and metastatic, were made, including hepatocellular carcinoma, cholangiocarcinoma and lymphoma. In addition, we have noted a significant increase in the number of EUS-FNAs in recent years. Conclusion: EUS-FNA is an effective and increasingly utilized diagnostic approach for the evaluation of multiple types of lesions in the porta hepatis.

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“…An alternative method is liquid-based cytology. This technique may lead to a reduction of inadequate samples [58]. All the material is expelled in a vial containing an alcoholbased fixative.…”

Section: Cytological Specimen Handling and Preparationmentioning

confidence: 99%

The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group

Thunnissen

Kerr

Herth³

et al. 2012

Lung Cancer

204

219

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Optimizing specimen collection and laboratory procedures reduces the non‐diagnostic rate for endoscopic ultrasound‐guided fine‐needle aspiration of solid lesions of the pancreas

Abstract: This study shows that accurate EUS-FNA results may be obtained with a low non-diagnostic rate comparable to those reported for rapid on-site evaluation by optimizing laboratory specimen processing in a setting of solid pancreatic lesions.

Cited by 28 publications

References 33 publications

Diagnostic Performance of Endoscopic Ultrasound (EUS)/ Endoscopic Ultrasound – Fine Needle Aspiration (EUS-FNA) Cytology in Solid and Cystic Pancreatic Neuroendocrine Tumours

Diagnostic Performance of Endoscopic Ultrasound (EUS)/ Endoscopic Ultrasound – Fine Needle Aspiration (EUS-FNA) Cytology in Solid and Cystic Pancreatic Neuroendocrine Tumours

Diagnostic Yield of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology of Porta Hepatis Lesions: A Retrospective Study

The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group

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