Optimizing the action of laser radiation on soft biological tissues

Беликов, А. В.; Karasev, V. B.; Pushkareva, A. E.; Skripnik, A. V.; Ovcharenko, Ya. S.; Khramov, V. Yu.; Smirnov, M. Z.

doi:10.1364/jot.75.000008

Cited by 1 publication

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“…This simplification is widely used by many authors to simulate the propagation of laser radiation and heat in similar tasks [22, 65–68]. Our results agree with previous simulations [68–70], demonstrating stronger skin heating than a tumor without additional absorbers in the form of plasmonic nanoparticles or dyes. This effect is associated with the accumulation of heat in the basal layer of the skin caused by the lack of blood flow and, consequently, intensive heat removal.…”

Section: Resultssupporting

confidence: 90%

Monitoring of optical properties of tumors during laser plasmon photothermal therapy

Genin,

Bucharskaya,

Kirillin

et al. 2024

Journal of Biophotonics

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We studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near‐infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures.

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Section: Resultssupporting

confidence: 90%