Optimizing the hybrid nanostructure of functionalized reduced graphene oxide/silver for highly efficient cancer nanotherapy

Golzar, H.; Yazdian, Fatemeh; Hashemi, Mohadeseh; Omidi, Meisam; Mohammadrezaei, Dorsa; Rashedi, Hamid; Farahani, Masoumeh; Ghasemi, Nazanin; Shayeh, Javad Shabani; Tayebi, Lobat

doi:10.1039/c8nj01764f

Cited by 22 publications

(7 citation statements)

References 75 publications

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“…For example, Golzar et al. reported a 1050 cm −1 peak for the C–O bond, 1200 cm −1 for C–O–C, 1600 cm −1 for COOH, and 1700 cm −1 peak for the C=O bond.…”

Section: Resultsmentioning

confidence: 99%

“…Graphene, as a class of two‐dimensional nanomaterials, has attracted extensive attention in various fields including nanoelectronic devices, transparent conductors, energy, and catalysis. Owing to their intrinsic physical and chemical properties, graphene, graphene derivatives, and various graphene‐based nanocomposites have also been widely explored in the area of biomedicine for application in sensing systems , bioimaging , drug delivery , gene delivery , different types of cancer therapies , and tissue engineering . Graphene oxide as a beneficial derivative of graphene has the highest surface area between all known nanomaterials for drug delivery purposes.…”

Section: Introductionmentioning

confidence: 99%

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Graphene oxide‐l‐arginine nanogel: A pH‐sensitive fluorouracil nanocarrier

Malekimusavi

Ghaemi

Masoudi

et al. 2019

Biotech and App Biochem

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Nowadays, putting forward an accurate cancer therapy method with minimal side effects is an important topic of research. Nanostructures, for their ability in controlled and targeted drug release on specific cells, are critical materials in this field. In this study, a pH‐sensitive graphene oxide‐l‐arginine nanogel was synthesized to carry and release 5‐fluorouracil. Optimized conditions using statistical analysis, based on the maximum relative viscosity of nanogel, were evaluated: 5.489 for the concentration of l‐arginine and 2.404 for pH. The prepared nanogels were characterized using scanning electron microscope and transmission electron microscope images and Fourier‐transform infrared spectroscopic analysis. Cytotoxicity was assessed using the sulforhodamine B (SRB) assay on MCF‐7 breast cancer cells. The fluorouracil release was measured by the dialysis bag method, UV spectrophotometry, and fluorouracil calibration diagram. Results proved the successful controlled release of fluorouracil at pH 5.4 and the beneficial role of graphene‐oxide‐ l‐arginine‐ fluorouracil nanogel in eliminating cancer cells.

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“…For example, Golzar et al. reported a 1050 cm −1 peak for the C–O bond, 1200 cm −1 for C–O–C, 1600 cm −1 for COOH, and 1700 cm −1 peak for the C=O bond.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Graphene oxide‐l‐arginine nanogel: A pH‐sensitive fluorouracil nanocarrier

Malekimusavi

Ghaemi

Masoudi

et al. 2019

Biotech and App Biochem

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“…Ltd.) was used to evaluate the absorbance of the samples (at a wavelength of 540 nm with a reference wavelength). The following equation was used to calculate cell viability [ 42,43 ] :

Mean absorbance goodbreak= \begin{matrix} lefttrue \\ \frac{value of treatment group - blank mean viability}{mean absorbance value of control - blank} * 100 \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

“…Ltd.) was used to evaluate the absorbance of the samples (at a wavelength of 540 nm with a reference wavelength). The following equation was used to calculate cell viability [42,43] :…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

et al. 2023

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Smart drug delivery systems have attracted a lot of attention as one of the new treatment methods for cancer. In this study, a smart drug delivery system carrying anticancer drugs was obtained by the intelligent synthesis of glucosamine (GA)‐functionalized graphene oxide (GO)‐based iron oxide nanoparticles (Fe3O4@GO‐GA) using Hummers and chemical co‐precipitation processes. Nanohybrids have a high surface area (280.26 m2/g) and superparamagnetic behaviour (Ms = 26.017 emu/g), indicating a significant loading capacity (373.78 mg/mg) and efficiency (96.3%) for pharmaceutical loading. An adsorption study of conventional daunorubicin (DNR) on this carrier showed that the drug release is more prone to occur under acidic conditions (pH = 5.5), at moderately high temperatures (T = 40°C), and in the absence of smart carriers. The toxicity of the smart nanohybrids was examined using the sulphorhodamine B (SRB) assay in Michigan Cancer Foundation‐7 (MCF‐7) cell lines. The rate of death of cells exposed to smart drug‐containing systems in comparison to the systems without GA shows that GA reduces the toxicity of Fe3O4@GO.

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“…Graphene oxide (GO), a new type of inorganic freemetallic material, has been widely investigated in drug delivery due to its unique features, such as good biocompatibility, low cost, and simple preparation [14][15][16][17]. Notably, graphene oxide can effectively transform light to heat when triggered by NIR irradiation [18][19][20], becoming a promising strategy to improve the photothermal therapy effect of cancer. Chen group has reported that GO could deliver the anticancer drugs by non-covalent interaction such as π-π stacking, hydrogen bonding, and electrostatic adsorption [21].…”

Section: Introductionmentioning

confidence: 99%

Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy

et al. 2020

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Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe 3 O 4-decorated hollow graphene microspheres (rGO@Fe 3 O 4) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemophotothermal combination therapy. The microspheres displayed very high specific surface area (~120.7 m 2 g −1) and large pore volume (~1.012 cm 3 g −1), demonstrating distinct advantages for a high loading capacity of DOX (1 8.43%). NIR triggered photothermal effect of the rGO@Fe 3 O 4 microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe 3 O 4 on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe 3 O 4 /DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe 3 O 4 /DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.

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Optimizing the hybrid nanostructure of functionalized reduced graphene oxide/silver for highly efficient cancer nanotherapy

Abstract: Conjugation of Herceptin to the surface of an optimized rGO-PLL/AgNP nanohybrid to achieve an efficient targeted DDS against Her2 positive breast cancer cells.

Cited by 22 publications

References 75 publications

Graphene oxide‐l‐arginine nanogel: A pH‐sensitive fluorouracil nanocarrier

Graphene oxide‐l‐arginine nanogel: A pH‐sensitive fluorouracil nanocarrier

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy

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