The selection of construction sites for Cultural and Museum Public Buildings (CMPBs) has a profound impact on their future operations and development. To enhance site selection and planning efficiency, we developed a predictive model integrating Artificial Neural Networks (ANNs) and Genetic Algorithms (GAs). Taking Shanghai as our case study, we utilized over 1.5 million points of interest data from Amap Visiting Vitality Values (VVVs) from Dianping and Shanghai’s administrative area map. We analyzed and compiled data for 344 sites, each containing 39 infrastructure data sets and one visit vitality data set for the ANN model input. The model was then tested with untrained data to predict VVVs based on the 39 input data sets. We conducted a multi-precision analysis to simulate various scenarios, assessing the model’s applicability at different scales. Combining GA with our approach, we predicted vitality improvements. This method and model can significantly contribute to the early planning, design, development, and operational management of CMPBs in the future.