Optimizing the metal ion release and antibacterial activity of ZnO@ZIF-8 by modulating its synthesis method

Kalati, Mona; Akhbari, Kamran

doi:10.1039/d1nj04534b

Cited by 25 publications

(19 citation statements)

References 37 publications

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“…The MOF nanomaterials exhibited exceptional antibacterial effect, particularly ZIF-67 43 . This is attributed to their porous structure and their ability to function as a source of metal ions 13 , 44 . Interestingly, Zheng et al have attributed the antibacterial activity of ZIF-67 MOF to a chemical interaction mechanism through the ROS and found that ZIF-67 has a promising antibacterial activity against Gram-negative bacteria E.coli in destroying the bacterial membrane solutions 13 .…”

Section: Resultsmentioning

confidence: 99%

“…The Co 2+ ions that are present in the ZIF-67 MOF NPs have the ability to cause cell wall rupture by generating ROS mediated toxicity 13 . This structural changes and deformation in the bacterial cell wall lead to damages in the intracellular components, proteins, phosphate amine and fatty acid groups of the peptidoglycan in the bacterial cell wall 41 , 44 . Instantaneously, a complete breakdown of the glycan backbone and the phospholipid in addition to a DNA damage upon the exposure of the nanoparticles to the nucleus 40 .…”

Section: Resultsmentioning

confidence: 99%

“…Instantaneously, a complete breakdown of the glycan backbone and the phospholipid in addition to a DNA damage upon the exposure of the nanoparticles to the nucleus 40 . As a result of the generated ROS throughout the leaching process and due to the interaction of ZIF-67 MOF nanoparticulates with biological moieties of the bacterial cell wall, they initiating adverse effects on the cell wall constituents, and leading to cell rupture along with various other extracellular components disruption 40 , 44 . These trigger events make the ZIF-67 has a potential antibacterial agent.…”

Section: Resultsmentioning

confidence: 99%

“…This is in agreement with Kalati et al . who studied the effect of ZIF-8 MOF nanostructured as antibacterial agents, highlighting the harmful effect of different morphologies of nanomaterials against Gram-negative and Gram-positive bacteria for metal ion release for bacterial inactivation 44 .…”

Section: Resultsmentioning

confidence: 99%

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Computational and experimental elucidation of the boosted stability and antibacterial activity of ZIF-67 upon optimized encapsulation with polyoxometalates

Mohamed

Abbas

Khedr

et al. 2022

Sci Rep

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Water microbial purification is one of the hottest topics that threats human morbidity and mortality. It is indispensable to purify water using antimicrobial agents combined with several technologies and systems. Herein, we introduce a class of nanosized metal organic framework; Zeolitic imidazolate framework (ZIF-67) cages encapsulated with polyoxometalates synthesized via facile one-step co-precipitation method. We employed two types of polyoxometalates bioactive agents; phosphotungstic acid (PTA) and phosphomolybdic acid (PMA) that act as novel antibacterial purification agents. Several characterization techniques were utilized to investigate the morphological, structural, chemical, and physical properties such as FESEM, EDS, FTIR, XRD, and N2 adsorption/desorption isotherms techniques. The antibacterial assessment was evaluated using colony forming unit (CFU) against both Escherichia coli and Staphylococcus aureus as models of Gram-negative and Gram-positive bacteria, respectively. The PTA@ZIF-67 showed higher microbial inhibition against both Gram-positive and Gram-negative bacteria by 98.8% and 84.6%, respectively. Furthermore, computational modeling using density functional theory was conducted to evaluate the antibacterial efficacy of PTA when compared to PMA. The computational and experimental findings demonstrate that the fabricated POM@ZIF-67 materials exhibited outstanding bactericidal effect against both Gram-negative and Gram-positive bacteria and effectively purify contaminated water.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Computational and experimental elucidation of the boosted stability and antibacterial activity of ZIF-67 upon optimized encapsulation with polyoxometalates

Mohamed

Abbas

Khedr

et al. 2022

Sci Rep

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“…Furthermore, traditional ZIF-8 can also release zinc ions and 2-methylimidazole to kill E. coli effectively under a variety of environmental conditions [ 19 ]. However, light-driven inactivation of bacteria as a photocatalyst is the main source of antibacterial ability in traditional ZIF-8 [ 20 , 21 , 22 ]. However, ZIF-8 has not been directly used to inhibit Gram-positive S. aureus to date.…”

Section: Introductionmentioning

confidence: 99%

A Cruciform Petal-like (ZIF-8) with Bactericidal Activity against Foodborne Gram-Positive Bacteria for Antibacterial Food Packaging

Shen¹,

Wang²,

Wang

et al. 2022

IJMS

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Most antibacterial nanomaterials used in food packaging act by releasing reactive oxygen species (ROS), which cannot efficiently have an inhibitory effect by penetrating the cell wall of Gram-positive Staphylococcus aureus. In this work, we used the cruciform petal-like zeolite imidazole framework-8 (ZIF-8) synthesized in the water phase which can release active Zn compounds in aqueous solution and exert a stronger inhibitory effect on S. aureus. The experimental results demonstrated that the aqueous cruciform petal-like ZIF-8 has the same photocatalytic activity as traditional ZIF-8 and can be applied in photocatalytic bacterial inactivation. The cruciform petal-like ZIF-8 was also shown to release active Zn compounds in aqueous solution with a better antibacterial effect against S. aureus, reaching 95% inactivation efficiency. The antibacterial effect was therefore 70% higher than that of traditional ZIF-8. Based on its excellent antibacterial properties, we loaded petal-like ZIF-8, PDA and PVA onto ordinary fibers to prepare ZIF-8-Film. The results further showed that ZIF-8-Film has a high filtration capacity, which can be used in antibacterial packaging material with the required air permeability. Moreover, ZIF-8-Flim can clean the surface on its own and can maintain a sterile environment. It is different from other disposable materials on the market in that it can be reused and has a self-disinfection function.

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Modulated antibacterial activity in ZnO@MIL‐53(Fe) and CuO@MIL‐53(Fe) nanocomposites prepared by simple thermal treatment process

Arshadi Edlo,

Akhbari

2023

Applied Organom Chemis

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By controlling the release of encapsulated antibacterial materials and the intrinsic antibacterial components of metal–organic frameworks (MOFs) through the slow degradation of their frameworks, the composite material that contains self‐degrading MOFs demonstrates synergistic antibacterial effects. In this study, MIL‐53(Fe) was investigated for finding MOFs that have metal oxides in the pores ([CuO]1.3@MIL‐53(Fe) and [ZnO]1.05@MIL‐53(Fe)) with antibacterial activity. MIL‐53(Fe) exhibits a significant surface area and precise pore structure, so it was a good choice for this study. MIL‐53(Fe) was synthesized by solvothermal method, and [Cu (CH3COO)2.H2O]1.0@MIL‐53(Fe) and [Zn (CH3COO)2.2H2O]0.5@MIL‐53(Fe) were prepared by immersion of the MOF in aqueous solution of [Cu (CH3COO)2.H2O] and [Zn (CH3COO)2.2H2O], respectively. Then, the [MO]x@MIL‐53(Fe) nanocomposites were prepared by thermal treatment of [Cu (CH3COO)2.H2O]1.0@MIL‐53(Fe) and [Zn (CH3COO)2.2H2O]0.5@MIL‐53(Fe) at 310°C and 290°C in N2 atmosphere, respectively. Fourier Transform Infrared Spectrometer, X‐ray powder diffraction, inductively coupled plasma–Optical Emission Spectrometry, Field Emission Scanning Electron Microscope, energy‐dispersive spectrometer‐mapping, and thermogravimetric analysis analyses were proved the successful synthesis of these compounds. Finally, the antibacterial activity of the composites was assessed against both Gram‐positive bacteria (Staphylococcus aureus) and Gram‐negative bacteria (Escherichia coli).

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Optimizing the metal ion release and antibacterial activity of ZnO@ZIF-8 by modulating its synthesis method

Abstract: An excellent feature of [ZnO]0.181@ZIF-8 is its slower release of Zn2+ ions as compared to Zn(CH3COO)2.2H2O.

Cited by 25 publications

References 37 publications

Computational and experimental elucidation of the boosted stability and antibacterial activity of ZIF-67 upon optimized encapsulation with polyoxometalates

Computational and experimental elucidation of the boosted stability and antibacterial activity of ZIF-67 upon optimized encapsulation with polyoxometalates

A Cruciform Petal-like (ZIF-8) with Bactericidal Activity against Foodborne Gram-Positive Bacteria for Antibacterial Food Packaging

Modulated antibacterial activity in ZnO@MIL‐53(Fe) and CuO@MIL‐53(Fe) nanocomposites prepared by simple thermal treatment process

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