Placing micro-textures on a tool surface can play an anti-wear and friction-reducing role and capture impurities and improve the tool-chip friction state, thus improving the cutting performance of the tool and the quality of the workpiece. To ensure the processing quality in the micro-texture-coated tool-cutting process, the process parameters and micro-texture parameters are limited to smaller parameters, which reduces the processing efficiency and increases the cost. Aiming at this problem, this paper designs orthogonal experiments of the cutting process and micro-texture parameters, builds an experimental platform for milling titanium alloy with a micro-texture-coated ball-end milling cutter, analyzes the influence of cutting parameters on tool milling performance and workpiece quality, establishes a high fitting prediction model, and optimizes parameters. The results show that the cutting parameters significantly affect the milling force, tool wear, and workpiece surface roughness, which are in the first response level, and the micro-texture parameters, which are in the second response level. It is proven that micro-texture has anti-wear and anti-friction effects, and it is found that micro-texture parameters affect the evaluation index by changing the distribution state of the micro-texture. It is found that the multiple linear regression model fits better. Parameter optimization results are: v = 159.4232 (m/min), ap = 0.211 (mm), f = 0.06 (mm/r), micro-pit diameter D = 62.3429 (μm), distance from blade L = 121.5184 (μm), and micro-pit spacing L1 = 235.6443 (μm). It provides some guidance for the selection of micro-texture parameters and cutting parameters on a micro-texture-coated tool.