In many large cities in developing countries, investments in transportation infrastructure are insufficient for the growing population, resulting in chronic traffic congestion and overcrowding. The urban population of developing countries is expected to increase further toward the middle of this century, and urban planning and transportation policies that foresee future population changes and economic growth are necessary to make these cities more sustainable. Bangkok is one of the most congested metropolitan areas in the world, and transport projects such as the extension of the public transportation system are being implemented. However, due to the monocentric urban structure, both road and rail traffic is extremely congested during peak hours, which impedes some economic activities and personal interaction. In this study, we simulate the impact of urban and transportation measures in Bangkok from today to 2050. In addition to the expansion of the planned rail transit network, we evaluate the effects of a land use scenario in which sub-centers are established to develop a polycentric urban structure. The impact of alternative zoning and transportation policies and projects in Bangkok is discussed. Although this study is focused on Bangkok, the findings are assumed to be transferable to other large cities in developing countries.