Optimizing the outcome of pregnancy in obese women: From pregestational to long-term management

Galtier, Florence; Raingeard, I.; Renard, Éric; Boulot, P.; Bringer, J.

doi:10.1016/j.diabet.2007.12.001

Cited by 50 publications

(57 citation statements)

References 46 publications

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“…Maternal obesity is also associated with fetal overgrowth and an increased risk of pregnancy complications (Galtier et al, 2008;Guelinckx et al, 2008;Robinson et al, 2005). Pre-pregnancy body mass index (BMI, calculated by dividing weight by height 2 ) correlates with fetal birthweight and placental weight in normal, uncomplicated, term singleton pregnancies without diabetes (Swanson and Bewtra, 2008).…”

Section: Placental System a And Fetal Overgrowthmentioning

confidence: 99%

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

147

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This review considers mechanisms by which transfer across the placenta takes place and how the capacity of the placenta to supply nutrients relates to fetal growth and vice versa. Blood flow through both uterine and umbilical circulations of the placenta, the structural properties of the placental exchange barrier and its related diffusional permeability, and the expression and activity of a wide range of transporter proteins in the syncytiotrophoblast, the transporting epithelium of the placenta, all need to be taken into account in considering placental supply capacity. We discuss the evidence that each of these factors affects, and is affected by, fetal growth rate and consider the regulatory mechanisms involved, with a particular focus on data that has emerged from study of the system A amino acid transporter. We consider that future work will build on the considerable foundation of knowledge regarding placental transfer mechanisms, as well as the other aspects of placental structure and function, to develop new diagnostic and therapeutic strategies for pregnancy complications, such as fetal growth restriction or overgrowth.

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Section: Placental System a And Fetal Overgrowthmentioning

confidence: 99%

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

147

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“…Useful protein sources can be meat, fish, cheese and dairy products (source of calcium), supplemented with small amounts of butter and vegetable fats. 19 Micronutrients are critical for women"s health during reproductive years and during pregnancy as well as during adolescence and post-menopausal period. 3 The adverse effects of micronutrient deficiencies on the health and birth outcome of women are well known.…”

Section: Dietmentioning

confidence: 99%

Healthy Diet and Nutrition Education Program among Women of Reproductive Age: a Necessity of Multilevel Strategies or Community Responsibility

Dunneram¹,

Jeewon²

2015

Health Promot Perspect

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Article type: Review ArticleBackground: Reproductive years represent a major proportion of women"s life. This review focuses on recommended nutritional considerations, physical activity pattern as well as the effect of nutrition education (NE) on behavior modification and health outcomes of women of reproductive age using either singlelevel, multiple-level or community-level interventions. Methods: For this narrative review, numerous searches were conducted on databases of PubMed, Science Direct and Google Scholar search engine using the keywords women, reproductive age, NE, interventions, community-based. Results: Even though single intervention is effective, multiple intervention programmes in addition to behavior modification components are even more successful in terms of modified behaviors and health outcomes. Moreover, community based interventions using multilevel strategies are further useful for improved health outcomes and behavior modification. Conclusion: NE programmes have been effective in positive behavior modification measured in terms of eating pattern and health quality. Thus, it is recommended that health professionals use multiple intervention strategies at community level to ensure improved outcomes. Political support is also required to create culturally sensitive methods of delivering nutritional programmes. Finally, as policy is dependent on program cost, nutritional programmes need to combine methods of cost analysis to show cost effectiveness of supplying adequate nutrition for women throughout the lifecycle.

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“…Macrosomic babies have increased rates of birth trauma, shoulder dystocia, respiratory distress syndrome and cesarean delivery (Galtier et al 2008;Yogev and Catalano 2009).…”

Section: Introductionmentioning

confidence: 99%

Placental infiltration of inflammatory markers in gestational diabetic women

Mrizak¹,

Grissa²,

Henault³

et al. 2014

gpb

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Abstract. Gestational diabetes mellitus (GDM) is pathology of glucose intolerance during pregnancy. It is influenced by maternal hyperglycemia and insulinemia through placental circulation. The study was undertaken to investigate the implication of pro-inflammatory factors in the placenta of GDM women. Thirty GDM women have delivered macrosomic babies, and 30 healthy age-matched pregnant women have delivered non macrosomic babies, were recruited in the study. The mRNAs encoding for IL-6, TLR4, TGF-β, CD68, CD14, EMR-1, CCL2, TCR-α, T-bet, GATA-3, leptin and adiponectin were quantified in placental samples by using RT-qPCR. The mRNA expression of the pro-inflammatory factors, i.e., IL-6, TLR4 and TGF-β, was increased in GDM placenta. The mRNA expression of markers of infiltration of macrophage, i.e., CD68, CD14 and EMR-1, was higher in the GDM placenta than the control placenta. The expression of mRNA of TCR-α, an indicator of T-cell infiltration, was significantly higher in the GDM placenta. Interestingly, the expression of mRNA of GATA-3, an indicator of Th2 phenotype differentiation, was unregulated in the GDM placenta. Leptin and adiponectin mRNAs were also significantly increased in the placenta of the GDM group. Our results revealed that there is an increase of inflammation in the GDM placenta which might be involved, in part, in the pathogenesis of macrosomia.

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Optimizing the outcome of pregnancy in obese women: From pregestational to long-term management

Cited by 50 publications

References 46 publications

Placental nutrient supply and fetal growth

Placental nutrient supply and fetal growth

Healthy Diet and Nutrition Education Program among Women of Reproductive Age: a Necessity of Multilevel Strategies or Community Responsibility

Placental infiltration of inflammatory markers in gestational diabetic women

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