Lifestyle choices significantly shape the intricate chemical makeup of the human body, impacting health and lifespan. The use of bio-chemical adsorbents in multistage potable water filtration represents a major breakthrough in addressing global water quality challenges. The fundamentals of bio-chemical adsorbents are discussed, distinguishing between bio-based and chemical materials and highlighting various types such as activated carbon, biochar, and graphene oxide. The concept of multistage filtration systems is introduced by major advantages over single-stage systems and key design considerations. The chapter then delves into the applications of bio-chemical adsorbents in water purification, presenting case studies and comparative analyses with traditional methods to demonstrate their efficacy and performance metrics. Strategies to enhance adsorption efficiency through surface modifications, hybrid systems, and composite materials are explored in detail with targets on environmental impact, sustainability, regulatory standards, and future trends on bio-chemical adsorbents.