The main energy input of a desiccant air conditioning system is the low-quality thermal ener-gy required for regeneration, which can be obtained from waste heat, geothermal resources or solar energy. Regeneration thermal energy can be produced as well as energizing components such as fans, pumps, auxiliary air heaters, and control elements of the system by using pho-tovoltaic-thermal solar collectors (PV/T). In this study, parametric analyzes were performed to investigate the effect of regeneration temperature and air frontal velocity on the tempera-ture and dehumidification performance of a solid silica-gel desiccant wheel and on the wa-ter-cooled PV/T collectors used to provide the regeneration thermal energy. The regeneration temperature was varied between 50 and 70°C, and air frontal velocity between 1.3 and 4.1 m/s. The analyzes show that the dehumidification efficiency increases from 13.94% to 33.04% as regeneration temperature increased from 50°C to 70°C at 1.3 m/s air frontal velocity at which dehumidification efficiency is maximum. At 4.1 m/s air frontal velocity, the required regener-ation thermal energy is maximum and increases from 49.64 kW to 132.48 kW at the same re-generation temperature change. The low regeneration temperature resulted in desirable latent performance and undesirable sensible heat transfer performance in DEW. Finally, considering the whole system, it was concluded that the optimum regeneration air temperature for the performance parameters is 60°C.