Optimum extraction Process of polyphenols from the bark of <i>Phyllanthus emblica</i> L. based on the response surface methodology

Yang, Li; Jiang, Jianguo; Li, Weifeng; Chen, Jian; Wang, Dingyong; Zhu, Liang

doi:10.1002/jssc.200800744

Cited by 155 publications

(111 citation statements)

References 28 publications

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“…Box-Behnken designs for multivariate optimization are a class of rotatable or nearly rotatable secondorder designs based on the three-level incomplete factorial design (4). R 2 (adjusted determination coefficient) is the measure for determining the goodness-of-fit of the regression equation (5).…”

Section: Box-behnken Design For Response Surface Methodologymentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Lan

Lin

2014

Acta Pharmaceutica

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Evaluation of the antioxidant activity of Coreopsis tinctoria Nuff. and optimisation of isolation by response surface methodologyThe aim of the present study was to determine the antioxidant activity of Coreopsis tinctoria flowering tops (CTFT). Studies were conducted to obtain suitable extraction conditions for chlorogenic acid, quercetin, luteolin, apigenin and kaempferol, which were identified and quantified by HPLC. Response surface methodology was employed to optimise the ultrasound-assisted extraction conditions including extraction time, ethanol concentration and liquid-solid ratio. The antioxidant activity of the extracts was analysed using various antioxidant models, such as DPPH, ABTS and hydroxyl radical scavenging assay. CTFT extracted for 15.0 min with ethanol at a concentration of 60.4 % and with liquidsolid ratio 27.5:1 possessed a considerable amounts of total flavonoids and polyphenols (18.9 %). This extract showed higher scavenging activity of ABTS and hydroxyl radical activity than rutin, however not in the DPPH test. We may assume that CTFT possess antioxidant and free radical scavenging potentials.

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Section: Box-behnken Design For Response Surface Methodologymentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Lan

Lin

2014

Acta Pharmaceutica

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“…Low concentration of organic solvents could access to cells, but high concentration would cause protein denaturation, preventing the dissolution of polyphenols and then influencing the extraction rate (Chen et al 2013). Apart from polarity of the solvents, there were several factors such as solvent viscosity, surface tension and vapour pressure affecting extraction yield (Yang et al 2009). Comparing the maximum levels of TP in the extract with different solvents, TP content in the extract with 50 % ethanol was significant higher than that with 70 % methanol (P<0.05).…”

Section: Extraction Solventsmentioning

confidence: 99%

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

et al. 2014

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Asparagus residues were used as materials to obtain antioxidant compounds by solid-liquid extraction in this study. The effects of different extraction parameters including extraction solvents, time, temperature and liquid-solid ratio on the contents of total flavonoids, total phenolics and total antioxidant activity were investigated. Antioxidant activity of the extract from asparagus residues was evaluated by HPLC-ABTS· + and the bioactive components were identified by HPLC-MS/MS. The results showed that the extraction yield was significantly influenced (P<0.05) by solvent composition, extraction time and temperature. The appropriate parameters were preferred as extraction solvent of 50 % ethanol with liquid-solid ratio of 30:1, extraction temperature of 80°C and time of 2 h. Antioxidant activity evaluation of the extract indicated flavonoids and phenolics were dominant bioactive compounds. Five antioxidant compounds were identified as ferulic acid, kaempferol, quercetin, rutin and isorhamnetin.

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“…3a that EtOH concentration (%) plays a predominant role for the extraction of polyphenols as TP value significantly increased with the increase in EtOH concentration. This is due to the fact that high concentration of ethanol can cause denaturation of proteins, preventing the dissolution of polyphenols and thus influencing the rate of polyphenol extraction (Yang et al 2009). …”

Section: Direct Effects Of Variablesmentioning

confidence: 99%

“…3b. Hightemperature solvent can promote polysaccharides on cell wall to distribute to solvent and to weaken the integrity of the cell wall (Yang et al 2009). But, the polyphenol yield reduces if the extraction has been carried out above 50-55°C because it causes loss of solvent and promotes oxidation of polyphenols.…”

Section: Direct Effects Of Variablesmentioning

confidence: 99%

An approach towards optimization of the extraction of polyphenolic antioxidants from ginger (Zingiber officinale)

et al. 2012

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The present study aims to maximize the extraction of polyphenols from ginger (Zingiber officinale) through the statistical optimization of three influential process parameters ethanol (EtOH) proportion (%), temperature (°C) and extraction time (min). Response Surface Methodology (RSM) was employed to design experiments and study the interaction effects of these parameters on the extraction process. Analysis of Variance (ANOVA) was used for the analysis of regression coefficient, prediction of equation and case statistics. The optimum conditions for the maximum yield of polyphenols from each gram of ginger were found to be 75 % aqueous EtOH, 40°C temperature and extraction time of 60 min respectively. The order of relative importance of these three parameters was: EtOH > time > temperature. Antioxidant activity of the extracted polyphenols using optimized parameters was also determined by DPPH assay. DPPH radical scavenging activity of ginger extract was compared with Vitamin C and butyl hydroxy toluene (BHT). Finally, this study revealed a cost effective analytical model to maximize the extraction of polyphenols from ginger with higher antioxidant activity. It was also concluded that at lower concentration ethanolic extract of ginger possess high antioxidant activity in comparison with synthetic antioxidants like vitamin C or BHT and thus it can be applicable as potent natural antioxidant in food and pharmaceutical industries for the preparation of functional food.

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Optimum extraction Process of polyphenols from the bark of Phyllanthus emblica L. based on the response surface methodology

Cited by 155 publications

References 28 publications

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

An approach towards optimization of the extraction of polyphenolic antioxidants from ginger (Zingiber officinale)

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