Optineurin Functions for Optimal Immunity

Slowicka, Karolina; Loo, Geert

doi:10.3389/fimmu.2018.00769

Cited by 22 publications

(12 citation statements)

References 45 publications

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“…Optineurin (OPTN) is a 67 KDa intracellular protein found in different tissues and has various domains like C-terminal zinc finger, leucine zipper domain, a LIR domain, and ubiquitin binding in ABIN and NEMO domain (UBAN) domain ( Kim et al, 2016 ; Slowicka and van Loo, 2018 ). It also consists of coiled-coil motifs, which mediates its oligomerization.…”

Section: Optnmentioning

confidence: 99%

“…It also consists of coiled-coil motifs, which mediates its oligomerization. It is an important autophagy adaptor as demonstrated by its role in mitophagy, aggrephagy as well as xenophagy ( Wild et al, 2011 ; Heo et al, 2015 ; Richter et al, 2016 ; Slowicka and van Loo, 2018 ). The role of OPTN in mitophagy was established in studies, which show that mutations in OPTN are associated with amyotrophic lateral sclerosis (ALS) and glaucoma due to mitochondrial dysfunction ( Wong and Holzbaur, 2014 ).…”

Section: Optnmentioning

confidence: 99%

“…OPTN majorly inhibits inflammation by negatively regulating NF-κB signaling ( Nagabhushana et al, 2011 ; Slowicka and van Loo, 2018 ). It is capable of competing with NEMO, to bind to RIPK1, a major factor for activating NF-κB, thereby resulting in down-regulation of NF-κB ( Zhu et al, 2007 ).…”

Section: Optnmentioning

confidence: 99%

“…It has been reported that M1-linked polyubiquitination on the bacterial surface recruits OPTN via E3 ubiquitin ligase complex LUBAC. However, the recruitment of p62 and NDP52 occurs independently of LUBAC, demonstrating that the functions of few adaptors are not completely redundant ( Noad et al, 2017 ; Slowicka and van Loo, 2018 ). During Salmonella infections, TRIM32, an E3 ligase, interacts with TRIF and adds a layer of complexity in its selective degradation in TAX1BP1 dependent manner.…”

Section: Ubiquitin Ligases and Deubiquitinases In Intracellular Bactementioning

confidence: 99%

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Selective Autophagy and Xenophagy in Infection and Disease

Sharma

Verma

Seranova

et al. 2018

Front. Cell Dev. Biol.

195

171

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Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections. The ability of autophagy to tag and target intracellular pathogens toward lysosomal degradation is central to this key defense function. However, studies involving the role and regulation of autophagy during intracellular infections largely tend to ignore the housekeeping function of autophagy. A growing number of evidences now suggest that the housekeeping function of autophagy, rather than the direct pathogen degradation function, may play a decisive role to determine the outcome of infection and immunological balance. We discuss herein the studies that establish the homeostatic and anti-inflammatory function of autophagy, as well as role of bacterial effectors in modulating and coopting these functions. Given that the core autophagy machinery remains largely the same across diverse cargos, how selectivity plays out during intracellular infection remains intriguing. We explore here, the contrasting role of autophagy adaptors being both selective as well as pleotropic in functions and discuss whether E3 ligases could bring in the specificity to cargo selectivity.

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Section: Optnmentioning

confidence: 99%

Section: Optnmentioning

confidence: 99%

Section: Optnmentioning

confidence: 99%

Section: Ubiquitin Ligases and Deubiquitinases In Intracellular Bactementioning

confidence: 99%

See 2 more Smart Citations

Selective Autophagy and Xenophagy in Infection and Disease

Sharma

Verma

Seranova

et al. 2018

Front. Cell Dev. Biol.

195

171

View full text Add to dashboard Cite

show abstract

“…Optineurin (OPTN) is a 67 kDa intracellular protein distributed among different tissues, where it serves as an important autophagy adaptor involved in different types of autophagy (Wild et al, 2011;Heo et al, 2015;Richter et al, 2016;Slowicka and van Loo, 2018). Studies have proven that OPTN is necessary for limiting the proliferation of Salmonella following infection.…”

Section: Adaptors Of Salmonella Autophagymentioning

confidence: 99%

Salmonella Interacts With Autophagy to Offense or Defense

Shen

Zhang

et al. 2020

Front. Microbiol.

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Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and functional stability. However, when cells are faced with challenges, such as starvation or pathogenic infection, their level of autophagy increases significantly. Salmonella is a facultative intracellular pathogen, which imposes an economic burden on the poultry farming industry and human public health. Previous studies have shown that Salmonella can induce the autophagy of cells following invasion, which to a certain extent helps to protect the cells from bacterial colonization. This review summarizes the latest research in the field of Salmonella-induced autophagy, including: (i) the autophagy induction and escape mechanisms employed by Salmonella during the infection of host cells; (ii) the effect of autophagy on intracellular Salmonella; (iii) the important autophagy adaptors that recognize intracellular Salmonella in host cells; and (iv) the effect of autophagy-modulating drugs on Salmonella infection.

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Exploring the Function of OPTN From Multiple Dimensions

Guo,

Tian,

Xia

et al. 2024

Cell Biochemistry & Function

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Autophagy is an essential intracellular degradation system responsible for delivering cytoplasmic components to lysosomes. Within this intricate process, optineurin (OPTN), an autophagy receptor, has attracted extensive attention due to its multifaceted roles in the autophagy process. OPTN is regulated by various posttranslational modifications and actively participates in numerous signaling pathways and cellular processes. By exploring the regulatory mechanism of OPTN posttranslational modification, we can further understand the critical role of protein posttranslational modification in biological progress, such as autophagy. Additionally, OPTN is implicated in many human diseases, including rheumatoid arthritis, osteoporosis, and infectious diseases. And we delve into the inflammatory pathways regulated by OPTN and clarify how it regulates inflammatory diseases and cancer. We aim to enhance the understanding of OPTN's multifaceted functions in cellular processes and its implications in the pathogenesis of inflammatory diseases and cancer.

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Optineurin Functions for Optimal Immunity

Cited by 22 publications

References 45 publications

Selective Autophagy and Xenophagy in Infection and Disease

Selective Autophagy and Xenophagy in Infection and Disease

Salmonella Interacts With Autophagy to Offense or Defense

Exploring the Function of OPTN From Multiple Dimensions

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